具有神经内分泌分化性质贲门癌的临床病理特征分析  

Analysis of clinicopathological features of gastric cardia cancer with neuroendocrine cell differentiation

作　　者：陈广灿[1] 洪良利[2] 谢澳斯[1] 林雯婷[3] 郭丹[3] 刘淑慧[3] 

机构地区：[1]汕头大学医学院第一附属医院胃肠外科,广东省汕头515041 [2]汕头大学医学院第一附属医院病理科,广东省汕头515041 [3]汕头大学医学院病理教研室

出　　处：《中国基层医药》2015年第21期3201-3203,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省自然科学基金项目资助（2014A030310139）;广东省医学科研基金资助项目（B2015110）

摘　　要：目的：探讨具有神经内分泌分化（NED）性质贲门癌的临床病理特点。方法回顾性分析汕头大学医学院第一附属医院2007年9月至2014年10月收治的70例贲门癌伴 NED 患者与同期76例不伴 NED贲门癌患者的临床资料，比较两组患者的临床病理特征的差异。结果贲门癌伴 NED 患者突触素（Syn）和嗜铬素 A（CgA）的阳性率分别为43．2％和22．6％。两组患者的临床病理特征比较，肿瘤的分化程度差异有统计学意义（χ2＝4．989，P ＝0．026）。伴 NED 的贲门癌肿块更大、浸润也更明显，但差异无统计学意义。结论免疫组织化学染色对贲门癌伴 NED 的诊断具有重要价值。伴 NED 的贲门癌分化较差。Objective To investigate the clinicopathological features of gastric cardia cancer with neuroendo-crine cell differentiation（NED）.Methods From September 2007 to October 2014,the clinicopathological features of 70 gastric cardia cancer patients with NED and 76 cases without NED confirmed by surgical pathology specimens and immunohistochemistry （Syn and CgA）in the First Affiliated Hospital of Shantou University Medical College were ret-rospectively analyzed and compared.Results The positive expression rates of synaptophysin（Syn）and chromogranin A（CgA）were 43.2% and 22.6%,respectively.Tumor differentiation was significantly related with NED （χ2 =4.989,P =0.026）.Tumors with NED were larger and had deeper invasion,but they were not statistically significant. Conclusion Immunohistochemistry is important to the diagnosis of NED.Gastric cardia cancer with NED has poorer differentiation.

关 键 词：神经内分泌分化 贲门肿瘤 免疫组织化学 病理学 临床 

分 类 号：R735[医药卫生—肿瘤]