射频消融术联合肝动脉介入术治疗原发性肝癌的临床观察  

Clinical effect of radiofrequency ablation combined with transcatheter arterial chemoembolization for patients ;with hepatocellular carcinoma

作　　者：娄玥[1] 

机构地区：[1]绍兴第二医院普外科,浙江省绍兴312000

出　　处：《中国基层医药》2015年第21期3214-3216,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察射频消融术（RFA）联合肝动脉介入疗法对原发性肝癌（PLC）的有效性和安全性。方法选择 PLC 患者64例，按数字表法随机将64例患者分为两组，观察组和对照组各32例，观察组给予肝动脉插管栓塞化疗（TACE）联合 RFA 治疗，而对照组给予 TACE 治疗。治疗1年后，随访肿瘤缓解情况以及患者1、2、3年累积生存率和两组患者 AST、ALT 和γ-GT 的变化并进行比较。结果治疗1年后，观察组缓解率为71．9％（23／32），对照组为43．8％（14／32），两组缓解率差异有统计学意义（χ2＝5．189，P ＜0．05）；观察组1、2、3年累积生存率分别为65．6％（21／32）、65．6％（21／32）、62.5％（20／32），对照组分别为37．5％（12／32）、28．1％（9／32）、21．9％（7／32），两组差异均有统计学意义（χ2＝5．067、9．035、10．83，均 P ＜0．05）；治疗2个月后，观察组 AST、ALT 和γ-GT 均明显优于对照组（t ＝4．218、2．449、8．647，均 P ＜0．05）。结论RFA联合 TACE 治疗能明显改善 PLC 患者的临床症状，改善患者的肝功能，有助于延长患者生存时间。Objective To discuss the safety and feasibility of radiofrequency ablation （RFA）combined with transcatheter arterial chemoembolization（TACE）for patients with primary liver carcer（PLC）.Methods 64 cases with PLC were selected and randomly divided into two groups,32 cases in each group.The observation group accepted TACE combined with RFA therapy,while the control group only received TACE treatment.Term efficacy （after 1 year）and 1,2,3 -year survival rate were compared in the two groups.The changes of liver function parameters including aspartate aminotransferase （AST）,alanine aminotransferase （ALT） and γ-aminoacyl transferase （γ-GT）of the two groups were analyzed and compared.Results After 1 year of treatment,the remission rate was 71.9% （23 /32）in the observation group,which in the control group was 43.8% （14 /32）,the difference was statis-tically significant （χ2 =5.189,P 〈0.05）.The 1,2,3 -year cumulative survival rates were 65.6% （21 /32）,65.6%（21 /32）and 62.5% （20 /32）in the observation group,which in the control group were 37.5% （12 /32）,28.1%（9 /32）and 21.9% （7 /32）,the differences were statistically significant （χ2 =5.067,9.035,10.83,all P 〈0.05）. After 2 months of treatment,AST,ALT and γ-GT levels in the observation group were significantly higher than those in the control group（t =4.218,2.449,8.647,all P 〈0.05）.Conclusion TACE combined with RFA therapy can significantly improve the clinical symptoms of patients with PLC,which can improve liver function in patients and help prolong the survival time.

关 键 词：射频消融术 肝动脉插管栓塞化疗 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]