液态活检技术的发展及肿瘤领域的应用  

Recent advances of liquid biopsy and its application in medical oncology

作　　者：陈颖[1] 朱明华[1] 

机构地区：[1]第二军医大学附属长海医院病理科,上海200433

出　　处：《分子诊断与治疗杂志》2015年第6期361-366,共6页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81172310)

摘　　要：广义而言,液态活检是指以血液为主的体液标本中细胞及核酸的检测,包括了循环肿瘤细胞和游离DNA两大类。液态活检属于新型的无创性分子病理检测方式,具有广阔的临床应用前景;对于传统病理学而言,液态活检的出现既是机遇也是挑战。本文主要从分子检测技术以及临床应用价值这两方面综合阐述了液态活检作为一种新的非侵入式的检测方法在临床肿瘤早期诊断、筛查等领域的发展前景及面临的挑战。Liquid biopsy refers to the analyses of circulating tumor cells or cell-free fragments of DNA that mainly exist in the bloodstream and other body fluid. Liquid biopsy is a novel kind of non-invasive technique and has a wide prospect of clinical application in the molecular pathological field. The occurrence of liquid biopsy is both an opportunity and challenge towards traditional histopathology. In this paper,the advances in the emerging new techniques of liquid biopsy and its clinical application values in the field of cancer care, including prognosis assessment, early cancer screening and prediction of treatment responses will be reviewed.

关 键 词：液态活检 非侵入式检测 分子检测 

分 类 号：R730.4[医药卫生—肿瘤]