结肠癌组织中Cofilin-1蛋白的表达及临床病理意义  

Expression and clinicopathological significance of Cofilin-1 protein in colonic cancer

作　　者：刘艳[1] 林建姣[1] 胡红松[1] 刘荣火[1] 章任兵[2] 

机构地区：[1]深圳市龙岗区人民医院消化内科,广东深圳518172 [2]深圳市龙岗区人民医院病理科,广东深圳518172

出　　处：《海南医学》2015年第21期3130-3132,共3页Hainan Medical Journal

摘　　要：目的探讨结肠癌组织中Cofilin-1蛋白的表达及其与肿瘤侵袭和转移的关系。方法应用免疫组织化学SP法检测60例结肠癌组织、40例癌旁正常组织、26例转移淋巴结组织标本中Cofilin-1蛋白的表达水平,并结合临床病理参数进行分析。结果 Cofilin-1蛋白在结肠癌组织、转移淋巴结组织中表达率分别为76.7%、61.5%,均明显高于癌旁正常组织中的32.5%表达率。Cofilin-1在结肠癌组织、转移淋巴结组织中的表达率明显高于癌旁正常组织,差异均有统计学意义(P<0.05);Cofilin-1蛋白的表达水平与结肠癌组织分化程度、Dukes分期、浆膜侵犯及淋巴结转移有关(P<0.05),而与性别、年龄、肿瘤大小无明显相关(P>0.05);Cofilin-1与结肠癌预后密切相关(P<0.05)。结论检测Cofilin-1蛋白的表达有助于判断结肠癌的浸润、转移及预后。Objective To investigate the expression of Cofilin-1 protein and its clinicopathological signifi-cance in colonic cancer. Methods The expression of Cofilin-1 protein in 60 colonic cancer specimens, 40 adjacent normal tissues, 26 lymph node metastasis tissues was detected by SP method. Meanwhile, the relationship between the expression of Cofilin-1 and the clinical pathologic factors was analyzed. Results The positive rate of Cofilin-1 expres-sion was 76.7%in colonic cancer specimens, 61.5%in lymph node metastasis tissues, which were significantly higher than 32.5% in adjacent normal tissues （P〈0.05）. Positive expression of Cofilin-1 protein was significantly associated with histology grading, Dukes stage, serosal invasion and lymph node metastasis （P〈0.05）, but not with gender, age and the size of tutor （P〈0.05）. Cofilin-1 was closely related to the prognosis of colonic cancer （P〈0.05）. Conclusion The detection of Cofilin-1 protein can help judge the invasion, metastasis and prognosis of colonic cancer.

关 键 词：丝切蛋白-1 结肠癌 转移 预后 

分 类 号：R735.35[医药卫生—肿瘤]