谷胱甘肽S转移酶基因多态性与中国人群骨肉瘤化疗敏感性的meta分析  

Gene polymorphism of glutathion S-transferase and chemosensitivity of osteosarcoma in Chinese population: a meta-analysis

作　　者：全忠 王帅[2] 刘毅 

机构地区：[1]老河口市第一人民医院骨科病区,湖北老河口441800 [2]襄阳市解放军477医院骨科病区,湖北襄阳441800

出　　处：《海南医学》2015年第21期3229-3233,共5页Hainan Medical Journal

摘　　要：目的系统评估谷胱甘肽S转移酶GSTTl、SGTMl、GSTPl基因多态性与中国人群骨肉瘤化疗敏感性。方法计算机检索PubMed、Embase、WebofScience、CochraneLibrary、中国知网（CNKI）、维普（VIP）、万方数据库及中国生物医药文献数据库（CBD），收集有关GSTMl、GSTTl、GSTPl与中国人群骨肉瘤化疗敏感性的研究，按照纳入和排除标准筛选文献，对符合标准的文献进行质量评价并提取数据，采用RevMan5．3、Statal2．0软件进行meta分析，计算合并OR值和95％CI，进行发表偏倚评价和敏感性分析。结果共纳入4篇文献由12个独立的研究组成，累计病例681例。Meta分析结果显示中国人群GSTTl（OR=0．92，95％CI=0．68～1．25，P=0．59）、GSTMI（OR=0．93，95％CI=0．68-1．26，P=-0．63）缺失型与正常型及GSTPl各遗传模型（GGVSAA＋AG，OR=0．61，95％CI=0．34～1．11，P=-0．11）对化疗的敏感性差异均无统计学意义，但GSTPlMeta分析稳健性欠佳。结论GSTTl、GSTMl基因多态性与中国人群骨肉瘤患者化疗敏感性无关。GSTPl基因多态性与中国人群骨肉瘤患者化疗敏感性可能无关，更进一步大样本研究是必要的。Objective To evaluate the gene polymorphism of glutathion S-transferase （GSTTI, SGTM1, GSTP 1） and chemosensitivity of osteosarcoma in Chinese population in order to obtain a more precise and comprehen- sive estimation of the telationshion. Methods An independently comprehensive electronic online search was conduct- ed in PubMed, Embase, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure （CNKI）, VIP, Wanfang Data, and the Chinese Biomedicine Database （CBD） to collect studies regarding glutathion S-transferase and chemosensitivity of osteosareoma in Chinese population. The data were screened based on the inclusion and exclu- sion criteria, and the qualified studies were evaluated. The pooled odds ratios （OR） with 95% confidence intervals were calculated using RevMan 5.3 and Stata 12.0 software. Publication bias and sensitivity analysis were also per- formed. Results Initially, 4 potentially relevant publications containing 12 separate studies involving 681 cases were included in the current meta-analysis. Results showed that the GSTT1 （Null vs Present, OR=0.92, 95% CI=0.68-1.25, P=0.59）, GSTM1 （Null vs Present OR=0.93, 95% CI=0.68-1.26, P=0.63）, GSTP1 （GG vs AA＋AG, OR=0.61, 95% CI= 0.34-1.1 I, P=0.11） polymorphism was not associated with chemosensitivity of osteosarcoma in Chinese population （P〉 0.05）. However, the robustness of the meta-analysis results of GSTP1 polymorphism was poor. Conclusion The cur- tent meta-analysis demonstrates that the GSTT1, GSTMI GSTP1 polymorphism may be not related to chernosensitivi- ty of osteosarcoma in Chinese population. Further studies with a larger sample size are needed to determine the associ- ation of GSTP 1 polymorphism and the chemosensitivity of osteosarcoma.

关 键 词：骨肉瘤 谷胱甘肽酶转移酶 基因多态性 META分析 

分 类 号：R738[医药卫生—肿瘤]