外周血miRNAs在应激性心肌病中的诊断作用  

Role of mi RNAs in the diagnosis of stress cardiomyopathy

作　　者：范致星 杨简[1] 

机构地区：[1]三峡大学心血管病研究所三峡大学第一临床医学院心内科,湖北宜昌443003

出　　处：《海南医学》2015年第22期3341-3343,共3页Hainan Medical Journal

基　　金：国家自然科学基金(编号:81170133;81200088;81470387);湖北省医学领军人才;三峡大学研究生科研创新基金项目

摘　　要：应激性心肌病又称为Tako-Tsubo综合征,绝经期后的女性常见,主要特点是可逆性室壁运动异常,临床表现与急性心肌梗死相似,冠状动脉造影一般正常,典型的左室造影表现为"章鱼篓"样。应激性心肌病发病之前多存在精神或躯体应激因素,主要发病机制可能为儿茶酚胺介导的心肌损伤。mi RNA作为一类具有调控功能的小分子非编码RNA,能通过与靶m RNA特异性结合来调节基因表达。体液中稳定表达的mi RNA与很多心血管疾病有密切关系,在心血管疾病的早期诊断中发挥了越来越重要的作用。Stress cardiomyopathy, also known as Tako-Tsubo syndrome, is a primary cardiomyopathy characterized with reversible ventricular wall motion abnormality. Its clinical manifestations are similar to acute myocardial infarction. Most patients had normal manifestations in coronary angiography（CAG）, but typical ＂chapter creel＂-like characteristics in left ventricular angiography. Stress cardiomyopathy is commonly seen in postmenopausal women and often caused by mental or physical stress factors. The pathogenesis remains unknown, but the consensus is the catecholamine-mediated myocardial injury. In cells, mi RNA-specific binding to the target m RNA could regulate gene expression. At the same time, the stable expression of mi RNA in body fluids is closely related to many cardiovascular diseases. In recent years, researches found that the peripheral blood mi RNAs could be used as potential biomarkers for the early diagnosis of cardiovascular disease.

关 键 词：应激性心肌病 TAKO-TSUBO综合征 MI RNAS 早期诊断 

分 类 号：R542.2[医药卫生—心血管疾病]