生育期妇女子宫颈上皮内瘤变高危型人乳头瘤病毒感染与Ki-67表达的相关性  

Correlation study between HR-HPV infection and Ki-67 expression in cervical intraepithelial neoplasia of reproductive women

作　　者：许莉莉[1] 胡晓霞[1] 莫云[1] 赵仁峰[1] 

机构地区：[1]广西壮族自治区人民医院妇产科,南宁530021

出　　处：《中国妇产科临床杂志》2015年第6期498-500,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：国家自然基金资助项目(81060219);广西医药卫生自筹经费计划课题资助项目(Z2014630)

摘　　要：目的探讨生育期妇女宫颈上皮内瘤变(CIN)中高危型人乳头瘤病毒(HR-HPV)感染与Ki-67表达的关系。方法通过第二代杂交捕获方法(HC2)检测248例生育期妇女HR-HPV感染情况,同时采用免疫组化法测定Ki-67的表达情况。结果 1正常或慢性宫颈炎组、CIN1、CIN2和CIN3组HR-HPV感染率分别为14%(7/50)、55.1%(38/69)、88.7%(63/71)和93.1%(54/58),差异有统计学意义(P<0.05);2各级别CIN患者HR-HPV载量明显高于正常或慢性宫颈炎组,差异有统计学意义(P<0.05),CIN各组HR-HPV载量两两比较,差异均有统计学意义(P<0.05);3 HR-HPV病毒载量与Ki-67呈正相关(r=0.817,P<0.05)。结论 HR-HPV载量持续高表达可能引起组织中Ki-67异常表达,可能是低级别CIN进展为高级别的原因。Objective To explore the correlation between high - risk human papilloma virus （HR-HPV） infection and Ki-67 expression in cervical intraepithelial neoplasia （CIN） of reproductive women. Methods HR-HPV infection was detected by Hybrid Capture 2 （HC-2） and Ki-67 expression was determined by immunohistochemical method in 248 reproductive women. Results The HR-HPV infection rate in normal or chronic cervicitis group and CIN1, 2, 3 group was 14.0% （7/50）, 55.1% （38/69）, 88.7% （63/71） and 93.1% （54/58） respectively, which was of significant in statistics （P 〈 0.05）. The HR-HPV viral load at all stages CIN was significantly higher than that in normal or chronic cervicitis group （P 〈 0.05）. And there was significant difference among all the three CIN groups （P 〈 0.05）. The HR-HPV viral load was positively correlated with Ki-67 expression （P 〈 0.05）. Conclusion The continuously high HR-HPV viral load may contribute for CIN progress to higher stages, and even to cercical carcinoma.

关 键 词：宫颈上皮内瘤变 高危型人乳头瘤病毒 KI-67 

分 类 号：R737.33[医药卫生—肿瘤]