Theoretical analysis of transcranial Hall-effect stimulation based on passive cable model  

作　　者：袁毅 李小俚 

机构地区：[1]Institute of Electrical Engineering, Yanshan University [2]State Key Laboratory of Cognitive Neuroscience and Learning & IDG,Mc Govern Institute for Brain Research, Beijing Normal University [3]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University

出　　处：《Chinese Physics B》2015年第12期373-378,共6页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Grant Nos.61273063 and 61503321);the China Postdoctoral Science Foundation(Grant No.2013M540215);the Natural Science Foundation of Hebei Province,China(Grant No.F2014203161);the Youth Research Program of Yanshan University,China(Grant No.02000134)

摘　　要：Transcranial Hall-effect stimulation（THS） is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field（due to Lorentz force）.In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.Transcranial Hall-effect stimulation（THS） is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field（due to Lorentz force）.In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.

关 键 词：HALL-EFFECT STIMULATION passive cable model neurons 

分 类 号：R312[医药卫生—基础医学]