酪蛋白磷酸肽钙磷复合体治疗正畸后釉质脱矿的临床研究  

Clinical study on remineralizing effect of CPP-ACP on enamel demineralization after orthodontic treatment

作　　者：聂琳 李佳岭[2] 马巧玲[2] 盛祖立 李诗佩 

机构地区：[1]杭州哼哈口腔医院综合科,浙江杭州310013 [2]南京大学医学院附属口腔医院正畸科,江苏南京210008

出　　处：《口腔医学》2015年第11期948-950,共3页Stomatology

摘　　要：目的研究酪蛋白磷酸肽钙磷复合体（CPP-ACP）对正畸后釉质脱矿的治疗作用。方法选择63例正畸治疗结束后,上牙（14~24,或15~25）唇面釉质存在轻度到中度脱矿的患者,随机分为2组：试验组31例,对照组32例。两组均给予含0.14%氟牙膏刷牙,每天晚上刷牙结束后试验组在脱矿牙牙面应用含有CPP-ACP的GC护牙素,对照组应用除不含CPP-ACP成分外,其他成分相同的安慰剂糊剂。临床检测指标为牙釉质脱矿指数（EDI）。观察时间为正畸结束当天,治疗1、3个月后,采用STATA12.0软件包对数据进行单因素方差分析。结果 58例完成试验（试验组28例,对照组30例）,两组EDI总和均较治疗前降低。治疗前,治疗1个月后3个月后试验组的EDI分别为（0.5903±0.2585）,（0.4514±0.2077）,（0.2396±0.1499）;对照组为（0.5291±0.2494）,（0.4397±0.2068）,（0.3287±0.1757）。治疗前和治疗1个月后两组EDI的差异无统计学意义,治疗3个月后试验组EDI少于对照组,差异有统计学意义。结论可以通过使用含CPP-ACP的GC护牙素来治疗正畸后釉质脱矿。Objective To assess the effectiveness of a ACP-CPP containing new product in reducing enamel demineralizationon postorthodontic patients. Methods The study design was double-blind,randomized clinical trial. 63 subjects with enamel decalcification（ not cavitated） on their upper teeth（ 14 ~ 24,or 15 ~ 25） were selected and randomly divided into two groups： the experimental group（ 31 cases） and the control group（ 32 cases）. The experimental group used GC Mousse while control group used placebo mousse（ without CCP-ACP） once a day at night after brushing with fluoride dentifrice. The Enamel Decalcification Index（ EDI） was used to determine the extent / severity of white enamel demineralizationat baseline,1 month and 3 months after treatment. A one-way analysis of variance（ ANOVA） was done with STATA 12. 0 software packagefor the average enamel decalcification index scores. Results 58 subjects completed the trial,with 28 in the experimental group and 30 in the control group. Baseline,1 month,3 months EDI of the experimental group were（ 0. 5903 ± 0. 2585）,（ 0. 4514 ± 0. 2077）,（ 0. 2396 ± 0. 1499）,respectively; and those for the control group were（ 0. 5291± 0. 2494）,（ 0. 4397 ± 0. 2068）,（ 0. 3287 ± 0. 1757）,respectively. The difference between the experimental group and control group was statistically significant 3 months after treatment. Conclusions The application of CPP-ACP can help reducing the number / extent of white spot lesions already present after fixed orthodontic treatment.

关 键 词：釉质 脱矿 CPP-ACP 再矿化 正畸治疗 

分 类 号：R783.5[医药卫生—口腔医学]