早期应用G-CSF联合地榆升白片干预升白治疗在肿瘤化疗中的效果分析  

Effect-analysis on the Intervention Therapy of G-CSF and Diyushengbai table early-used on the tumor-chemotherapy

作　　者：陈婵娟[1] 陈昌南[1] 林云笑[1] 谭斌[2] 潘岐作[1] 谢峰[1] 

机构地区：[1]广东省江门市新会区人民医院内三区,广东江门529100 [2]广东省江门市新会区人民医院中心药房,广东江门529100

出　　处：《吉林医学》2015年第17期3737-3738,共2页Jilin Medical Journal

摘　　要：目的:观察早期应用G-CSF联合地榆升白片干预升白治疗在肿瘤化疗中的疗效及安全性。方法:120例恶性肿瘤患者随机分成两组各60例,治疗组在化疗的同时给予地榆升白片治疗,结合血常规,早期预防性应用粒细胞集落刺激因子(G-CSF)升白治疗;对照组在化疗后出现Ⅱ度以上骨髓抑制才给予升白治疗,疗程6程。比较分析两组白细胞减少及生存质量情况。结果:治疗组化疗后出现白细胞减少12例(20%),Kps评分下降8例(12.5%),提高50例(83.33%),56例(93.33%)按期完成化疗;对照组化疗后出现白细胞减少33例(55%),Kps评分下降23例(38.33%),提高30例(50%),45例(75%)按期完成化疗,有2例因不良反应而中止化疗。两组比较差异有统计学意义(P<0.05)。结论:血常规指导下早期应用G-CSF联合地榆升白片干预升白治疗能显著减少肿瘤化疗后白细胞减少,保障化疗进行,提高生存质量,未发生严重不良反应。Objective To investigate the efficacy,safety and clinical significance of granulocyte Colony-stimulating Factor（ G-CSF）and Diyushengbai table early-used on the tumor-chemotherapy. Method 120 patients with cancer were divided into two groups,60 cases of each group. The therapy group received Diyushengbai table,early selectivity received G-CSF related to blood cell analysis（ BCA） at chemotherapy period,The control group received G-CSF and Diyushengbai table at the gap period aboveⅡgroup Leucopenia,two groups for 6 doses. Analyze the efficacy,side effects,quality of life in two groups. Results The treatment group： Leucopenia 12 cases（ 20%）,KPS score decreased 8 cases（ 12. 5%）,raised 50 cases（ 83. 33%）,56 cases（ 93. 33%） finished chemotherapy on time; The control group：Leucopenia 33 cases（ 55%）,KPS score decreased 23 cases（ 38. 33%）,raised 30 cases（ 50%）,45 cases（ 75%） finished chemotherapy on time,2 cases stopped chemotherapy due to adverse events. The difference was statistically significant（ P〈0. 05）. Conclusion G-CSF and Diyushengbai table early-used on the tumor-chemotherapy by the BCA has a certain effect,with a higher clinical benefit,low toxicity and good safety.

关 键 词：地榆升白片 粒细胞集落刺激因子 肿瘤化疗 白细胞减少 生存质量 

分 类 号：R730.53[医药卫生—肿瘤]