中国阿尔茨海默病患者血清促甲状腺激素水平的meta分析  

Meta analysis on the level of serum thyroid stimulating hormone in Chinese people with Alzheimer's disease

作　　者：张亚峰[1] 孙桂香[2] 王炳花[2] 

机构地区：[1]徐州医学院研究生学院,徐州221000 [2]徐州医学院流行病学教研室,徐州221000

出　　处：《郑州大学学报（医学版）》2015年第6期838-842,共5页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨中国阿尔茨海默病(AD)患者血清促甲状腺激素(TSH)水平的变化。方法:利用计算机及手工检索,全面检索AD患者血清TSH变化的病例对照研究,采用Stata 12.0进行meta分析。结果:共有16篇文献纳入分析,获得样本1 760例,其中病例组918例,对照组842例。Meta分析结果显示,AD患者血清TSH水平低于对照组(Z=1.987,P=0.046);失安全系数Nfs0.05为895;平均年龄为异质性因素,进一步对病例组平均年龄进行亚组分析,发现随着年龄增高,病例组和对照组之间的TSH水平差异更为明显(Z=2.110,P=0.003),采用随机效应模型合并分析的结果可靠。结论:中国AD患者TSH水平低于正常人群,低水平的血清TSH可能与AD发生、发展有关。Aim： To evaluate the change of the level of serum thyroid stimulating hormone in Chinese people with Alzheimer′s disease（AD）.Methods： The related articles of thyroid stimulating hormone and the case control studies of AD were retrieved comprehensively by manual retrieval and computer retrieval .The valid data were extracted and analyzed by Stata 12.0.Results：In this study, 16 studies were selected.A total of 1 760 subjects were enrolled, including 918 pa-tients and 842 controls.The Meta analysis showed that the serum level of thyroid stimulating hormone in patients with AD was lower than that in controls （Z=1.987,P=0.046）,and the loss of safety coefficient was 895.There was significantly decreasing trend in patients with AD in the subgroup analysis according to the age （Z=2.110,P=0.003）.The sensitivity analysis indicated that the result of Meta analysis was reliable .Conclusion： Serum thyroid stimulating hormone level de-creases more in patients with AD ,and low serum thyroid stimulating hormone level may relate to the development and cause of AD.

关 键 词：阿尔茨海默病 促甲状腺激素 META分析 

分 类 号：R741[医药卫生—神经病学与精神病学]