降钙素原测定在婴幼儿急性中耳炎治疗中的价值  

Clinical application value of serum procalcitonin in the treatment of Infant with acute otitis media

作　　者：李阳阳[1] 王小锐[2] 张蕊[3] 王东海[1] 张刚[1] 曾祥悦[4] 侯庆军[1] 罗宏伟[1] 

机构地区：[1]唐山市协和医院耳鼻咽喉头颈外科,河北唐山063000 [2]唐山市第二医院麻醉科,河北唐山063000 [3]唐山市协和医院检验科,河北唐山063000 [4]唐山职业技术学院耳鼻咽喉头颈外科教研室,河北唐山063000

出　　处：《国际检验医学杂志》2015年第A02期47-49,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清降钙素原（PCT）动态检测在婴幼儿急性中耳炎治疗中的临床应用价值，指导临床合理应用抗生素。方法随机将108名急性中耳炎患儿分为PCT组和常规治疗组，各54人，年龄6个月至3岁，PCT组根据PCT值使用抗生素：PCT值〈0．25μg／L时不应用抗生素，≥0.25μg／L则应用抗生素。常规治疗组依经验使用抗生素。比较两组惠儿治疗前后的体温（T）、血清降钙素原水平（PCT）、白细胞计数（WBC）、C反应蛋白值（CRP），比较两组治疗时间、抗生素应用时间、抗生素使用率、临床有效率。结果PCT组抗生素应用时间及抗生素使用率均明显小于常规治疗组，有统计学意义（P〈0．05），两组比较体温（T）、PCT、WBC、CRP、治疗时间、临床有效率均无统计学意义（P〉0．05）。结论在婴幼儿急性中耳炎治疗中，根据降钙素原水平（PCT）指导抗生素应用，可减少抗生素的使用，而不影响治疗效果，可降低滥用抗生素导致的风险．Objective To explore the clinical application value of the dynamic monitoring of serum procalcitonin（PCT） in the treatment of infant with acute otitis media,and to guilde clinical reasonable use of antibiotics. Methods 108 infants with acute otitis media were randomly divided into the PCT group（54 patients） and the routine therapy group（54 patients）, range 6 months to 3 years,in the PCT group, the dynamic monitoring of serum PCT levels were referenced to the quantity of antibiotic to administer： PCT〈0.25 μg/L don＇t use of antibiotics, ≥0.25 μg/L use of antibiotics;in the routine therapy group, antibiotics were adminis- tered according to the experience of doctors. The differences were compared between the two groups before and after treatment in infants with body temperature（T）, procalcitonin（PCT）, total white blood cells （WBC） and C-reactive protein （CRP）. Metrics corn pared between the two groups were duration and frequency of using antibiotic, the time of therapy and clinical effectiveness. Results The frequency and duration of using antibiotic in PCT groups was lower than the routine therapy group, the differences were sta- tistically significant（P〈0.05）. T, PCT, WBC, CRP, the time of therapy and clinical effectiveness had no significant difference between the two groups （P〉0.05）. Conclusion PCT levels can guide the use of antibiotic in treating of infants with acute otitis media, can reduce the use of antibiotics, without affecting the clinical effectiveness, to reduce the unnecessary antibiotic exposure.

关 键 词：降钙素原 急性中耳炎 抗生素 婴幼儿 

分 类 号：R737.9[医药卫生—肿瘤]