Bcl-2家族对线粒体质量控制的调控研究  

On mitochondrial quality control regulated by Bcl-2 family

作　　者：孙秀玉[1] 刘立亚[1] 吴宥熹 黄秀兰[1] 

机构地区：[1]中央民族大学中国少数民族传统医学国家民委-教育部重点实验室,北京100081

出　　处：《中国药理学通报》2015年第12期1633-1636,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81173656;81470182)

摘　　要：线粒体质量控制是维持细胞生存及生存状态的重要机制,通过对线粒体形态、数量与质量的多维调控,维持细胞内稳态。研究发现Bcl-2家族与线粒体多种功能的调控密切相关,并参与调控线粒体自噬/细胞凋亡互调节及线粒体分裂、融合的动态变化,是线粒体质量控制的关键调控因子。该文主要综述Bcl-2家族对线粒体质量控制的影响及其主要调控机制。Mitochondrial quality control is the important mechanism that regulates the morphology,quantity and quality of mitochondrial in cell to maintain cellular homeostasis and thus,cell survival and health. It has been revealed that members of Bcl-2family are linked to mitochondrial function and integrity. Bcl-2family proteins are the key regulators of mitochondrial quality control,participating in the signaling pathways regulating the crosstalk between mitophagy and apoptosis,as well as mitochondrial fission and fusion. This paper mainly reviews their impact on mitochondrial quality and the major signaling pathways regulated by Bcl-2 family proteins.

关 键 词：BCL-2家族蛋白 线粒体质量控制 线粒体自噬 细胞凋亡 线粒体分裂与融合 BNIP3 PINK1-Parkin通路 

分 类 号：R-05[医药卫生] R329.24