微管抑制剂诱导肿瘤细胞有丝分裂灾难研究进展  

Research progress of microtubule inhibitor-induced tumor cell mitotic catastrophe

作　　者：邹翔[1,2] 王超[2] 曲中原[3] 方月妮[2] 盛洁静[3] 季宇彬[1,2] 

机构地区：[1]哈尔滨商业大学国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076 [2]哈尔滨商业大学药物研究所博士后科研工作站,黑龙江哈尔滨150076 [3]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《中国药理学通报》2015年第12期1637-1640,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81102858);黑龙江省普通本科高等学校青年创新人才培养计划(No UNPYSCT-2015070);中国博士后科学基金项目(No2013M321060);黑龙江省博士后科研基金项目(No LBHZ11103)

摘　　要：微管抑制剂一直是抗肿瘤药物研究的热点。微管抑制剂通过促进或抑制微管的聚合来破坏微管的动态平衡,阻碍肿瘤细胞纺锤体形成,阻滞细胞分裂进程从而发挥抗肿瘤作用。有丝分裂灾难是发生在细胞有丝分裂期,由细胞分裂异常和纺锤体结构的损伤而造成的细胞死亡现象。近年来,微管抑制剂能够诱导肿瘤细胞发生有丝分裂灾难已被临床证实,并越来越受到人们关注。现对微管抑制剂的最新研究进展进行综述,并探讨其诱导肿瘤细胞发生有丝分裂灾难死亡的分子机制。Microtubule inhibitor has been a hot area of anticancer drugs research. Microtubule inhibitor exert an anti-tumor effect by promoting or inhibiting the microtubule aggregation to break the dynamic balance of microtubule,hindering the spindle formation of tumor cells,and then blocking the process of cell division. Mitotic catastrophe is a cell death phenomenon that is caused by abnormal cell division and damage of spindle structure in cell mitosis phase. In recent years more and more attention has been paid to mitotic catastrophe cell death because it has been confirmed clinically that microtubule inhibitors can induce mitotic catastrophe death of tumor cells. This paper reviews the latest research progress of microtubule inhibitors,and discusses the molecular mechanisms of mitotic catastrophe cell death tumor cells induced by microtubule inhibitors.

关 键 词：微管抑制剂 微管蛋白聚合剂 微管蛋白解聚剂 有丝分裂灾难 纺锤体组装检查点 分子机制 

分 类 号：R-05[医药卫生] R329.25