Schiff碱金属配合物抗肿瘤活性研究进展  

The Development On Antitumor Activities Of Schiff Bases And Metal Complexes Research

作　　者：钟霞[1] 刘雯清 陈年根[1] 高炳淼[1] 张俊清[1] 

机构地区：[1]海南医学院药学院,海南海口571199 [2]上海迪亚凯特生物科技有限公司,上海200120

出　　处：《中国卫生产业》2015年第16期111-113,共3页China Health Industry

基　　金：海南省自然科学基金(No.814287)资助课题

摘　　要：Schiff碱金属配合物抗肿瘤活性的研究已逐渐成为配位化学及抗肿瘤药物研究的热点,该文简要介绍了近年来国内、外Schiff碱金属配合物抗肿瘤活性的最新研究进展,揭示了其相关作用机制,并阐述了其作为新型抗肿瘤药的优势。对Schiff碱配体及金属进行合成、改造、组合和筛选,从而合成具有潜力的新型抗肿瘤药物,这对肿瘤化疗药的研发具有重要意义。Study on Schiff base metal complexes and their antitumor activities has gradually become the focus of coordination chemistry and antitumor drug research. The article gives brief introduction of recent research development on antitumor activities of Schiff bases and metal complexes, revealing the mechanism of the regulation, and expounding their advantage as a new anticancer drug. Schiff base ligands and metals are synthesized, transformed, combined and screened, so that it can synthesize the novel antitumor drugs, which has important significance for the research and development of tumor chemotherapy drugs.

关 键 词：SCHIFF碱 配合物 抗肿瘤活性 抗肿瘤药物 

分 类 号：R5[医药卫生—内科学]