微小RNA-30a在胃癌患者的表达及临床意义  

Expression and clinical significance of miRNA-30a in plasma of patients with gastric cancer

作　　者：周杰[1] 樊瑞智 李海青[2] 宋虎[2] 徐溢新[2] 徐为[2] 宋军[2] 

机构地区：[1]徐州医学院研究生院,江苏省221002 [2]徐州医学院附属医院胃肠外科

出　　处：《江苏医药》2015年第22期2682-2683,2687,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅面上科研项目(H201220);江苏省"六大人才高峰"项目(2012-WS-068);徐州市科技发展基金资助项目(KC134SH103)

摘　　要：目的探讨胃癌患者血浆微小RNA-30a(miRNA-30a)的表达及其临床意义。方法采用荧光定量PCR检测64例胃癌患者(A组)和36例健康人群(C组)血浆miRNA-30a的表达水平,分析其与胃癌临床病理参数间的关系。结果 A组miRNA-30a表达水平低于C组(0.436±0.261vs.0.599±0.348)(P<0.01)。miRNA-30a在胃癌患者血浆中的表达水平与胃癌的分化程度、侵润深度及淋巴结转移明显相关(P<0.05),但与患者的年龄、性别、肿瘤分期无显著相关(P>0.05)。结论 miRNA-30a在胃癌患者血浆中低表达,与胃癌发生和发展密切相关,可能成为胃癌早期诊断的指标之一。Objective To investigate the expression and clinical significance of microRNA-30a（miRNA-30a）in plasma of patients with gastric cancer.Methods Expressions of miRNA-30 ain plasma of 64 patients with gastric cancer（group A）and 36 healthy people（group C）were detected by fluorogenic quantitative PCR.The relationship between miRNA-30 aexpression and clinicopathological parameters of gastric cancer was analyzed.Results Plasma level of miRNA-30 aexpression in group A was lower than that in group C（0.436±0.261 vs.0.599±0.348）（P〈0.01）.miRNA-30 a expression was closely related to the degree of differentiation,local invasion depth and lymph node metastasis（P〈0.05）,but not associated with age,gender and clinical stage（P〉0.05）.Conclusion The expression of miRNA-30 ain plasma is down-regulated in the patients with gastric cancer,which is closely related to the occurrence and development of gastric cancer and may become one of the indicators in early diagnosis of gastric cancer.

关 键 词：微小RNA-30a 胃癌 

分 类 号：R735[医药卫生—肿瘤]