多西紫杉醇联合方案经动脉介入对结直肠癌肝转移患者近远期生存率的影响  

Effect of Docetaxel combined regimen transarterial interventional therapy on short and long-term survival rate of patients with liver metastasis of colorectal cancer

作　　者：马友龙[1] 

机构地区：[1]承德医学院附属医院外四科,河北承德067000

出　　处：《中国医药导报》2015年第34期78-81,89,共5页China Medical Herald

基　　金：河北省承德市科学技术研究与发展计划(自筹经费)项目(20122127)

摘　　要：目的研究多西紫杉醇联合方案经动脉介入对结直肠癌肝转移患者近远期生存率的影响。方法将2012年4月~2013年7月承德医学院附属医院收治的60例结肠癌肝转移患者纳入研究对象,采用随机数字表法分为观察组和对照组,各30例。观察组患者接受多西紫杉醇联合方案经动脉介入治疗,对照组患者接受多西紫杉醇联合方案静脉化疗,比较两组患者的生存率、肿瘤标志物以及生存质量。结果术后12、24个月时,观察组患者的生存率明显高于对照组（73.33%比53.33%,60.00%比36.67%）,差异有统计学意义（P〈0.05）;观察组治疗后,血清高尔基体蛋白73（GP73）、缺氧诱导因子（HIF-1α）、高迁移率族蛋白B1（HMGB1）含量明显低于对照组[（48.94±6.14）比（91.52±11.67）μg/L,（134.6±15.2）比（220.9±31.1）ng/L,（15.3±1.9）比（27.2±3.4）ng/L],差异有统计学意义（P〈0.05）;观察组治疗后,物质生活、躯体健康、心理健康、社会功能评分均高于对照组[（55.1±6.8）比（47.2±5.3）分,（64.1±7.9）比（50.4±6.9）分,（66.4±8.4）比（52.8±6.2）分,（61.9±8.1）比（50.9±6.2）分],差异有统计学意义（P〈0.05）。结论多西紫杉醇联合方案经动脉介入治疗有助于提高生存率,降低肿瘤标志物含量,改善生存质量。Objective To study the effect of Docetaxel combined regimen transarterial interventional therapy on short and long-term survival rate of patients with liver metastasis of colorectal cancer. Methods 60 cases of patients with liver metastasis of colorectal cancer in Chengde Medical College Affiliated Hospital from April 2012 to July 2013 were enrolled and randomly divided into observation group and control group, each group had 30 cases. Observation group received Docetaxel combined regimen transarterial interventional therapy, control group received Docetaxel combined regimen intravenous chemotherapy. Then survival rate, tumor markers and survival quality were compared. Results 12,24 months after operation, observation group survival rate were significantly higher than those of control group（73.33%vs 53.33%, 60.00% vs 36.67%）, with statistically significant differences（P〈0.05）. After treatment, serum GP73, HIF-1α, HMGB-1 contents of observation group were significantly lower than those of control group [（48.94 ±6.14） vs（91.52±11.67） μg/L,（134.6±15.2） vs（220.9±31.1） ng/L,（15.3±1.9） vs（27.2±3.4） ng/L], with statistically significant differences（P〈0.05）. After treatment, material life, physical health, mental health, social function dimensions scores of observation group were significantly higher than those of control group [（55.1 ±6.8） vs（47.2±5.3） points,（64.1 ±7.9） vs（50.4±6.9） points,（66.4±8.4） vs（52.8±6.2） points,（61.9±8.1） vs（50.9±6.2） points], with statistically significant differences（P〈0.05）. Conclusion Docetaxel combined regimen transarterial interventional therapy is helpful to increase survival rate, reduce tumor marker content, improve quality of life.

关 键 词：结直肠癌 肝转移 多西紫杉醇 介入治疗 肿瘤标志物 

分 类 号：R735.3[医药卫生—肿瘤]