视神经脊髓炎及多发性硬化患者脑部氢质子磁共振波谱分析  

Analysis on brain ^1H magnetic resonance spectroscopy characteristics of patients with neuromyelitis optica and multiple sclerosis

作　　者：肖丽[1] 邱伟[1] 陆正齐[1] 陈少琼[2] 胡学强[1] 

机构地区：[1]中山大学附属第三三医院神经内科,510630 [2]中山大学附属第三三医院放射科,510630

出　　处：《中国神经免疫学和神经病学杂志》2015年第6期385-388,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的通过氢质子磁共振波谱（^1H magnetic resonance spectroscopy,^1H-MRS）研究视神经脊髓炎（neuromyelitis optica,NMO）及多发性硬化（multiple sclerosis,MS）患者脑部病灶的特征。方法对24例NMO、26例MS患者脑内病灶及其对侧看似正常脑白质（normal appearing white matter,NAWM）进行^1H-MRS扫描,计算并比较各组患者两侧代谢产物〔N-乙酰门冬氨酸/肌酸（NAA/Cr）、胆碱/肌酸（Cho/Cr）、肌醇/肌酸（mI/Cr）〕比值。结果 MS患者脑内病灶NAA/Cr低于对侧NAWM（t=2.232,P=0.03）,Cho/Cr（t=1.56,P=0.12）及mI/Cr=（t=0.44,P=0.66）与对侧NAWM比较差异无统计学意义。NMO患者脑内病灶NAA/Cr（t=1.024,P=0.32）、Cho/Cr（t=0.643,P=0.52）及mI/Cr（t=1.267,P=0.23）与其对侧NAWM比较差异均无统计学意义。结论 MS脑内病灶可能存在严重的神经元轴突损害,而NMO脑内病灶可能无明显轴突损害。Objective To investigate ^1H magnetic resonance spectroscopy（^1H-MRS）features of the brain lesions in patients with neuromyelitis optica（NMO）and multiple sclerosis（MS）.Methods The clinical data,^1H-MRS features of brain lesions and normal appearing white matter（NAWM）in 24 NMO patients and 26 MS patients were reviewed.The ^1H-MRS features were represented by concentrations of metabolites including the ratios of N-acetyl aspartate to creatine（NAA/Cr）,choline-containing compounds to Cr（Cho/Cr）and myoinositol to Cr（mI/Cr）.Results Compared with the contralateral NAWM,NAA/Cr ratio of brain lesions in MS patients decreased significantly（t=2.232,P=0.03）while Cho/Cr and mI/Cr ratios increased（t=1.56,0.44,P〉0.05,respectively）.Compared with the contralateral NAWM,NAA/Cr,Cho/Cr and mI/Cr ratios of brain lesion in NMO patients decreased（t=1.024,0.643,1.267,P〉0.05,respectively）.Conclusions The neuronal/axonal injury may be severe in brain lesions of MS patients,but the neurons and axons of NMO patients may be normal.

关 键 词：视神经脊髓炎 多发性硬化 氢质子磁共振波谱 

分 类 号：R744.51[医药卫生—神经病学与精神病学] R744.52[医药卫生—临床医学]