肺癌中NR4A3和CD133表达的临床意义及相关性  

Expression and Clinical Significance of NR4A3 and CD133 in Non-small Cell Lung Cancer

作　　者：郭善娴 黄先明[1] 蔡勇[1] 简艳[1] 刘志良[1] 蔡云[1] 詹勤元[1] 钭方芳[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2015年第12期1782-1785,共4页The Practical Journal of Cancer

基　　金：江西省卫生计生委科技计划(编号:20151106)

摘　　要：目的探讨NR4A3和CD133蛋白在非小细胞肺癌中的表达,并结合临床病理特征来研究NR4A3的临床意义及与CD133相关性。方法应用免疫组织化学方法检测84例非小细胞肺癌组织及癌旁正常肺组织中NR4A3和CD133的表达。结果 NR4A3在癌旁正常肺组织阳性表达率为90.5%,肺癌组织为19.0%(P<0.05)。NR4A3的表达与肿瘤分化程度及吸烟有关(P<0.05),与患者的性别、年龄、病理类型,淋巴结转移和分期均无关(P>0.05)。NR4A3和CD133在非小细胞肺癌中的表达呈负相关(γ=-0.219,P<0.05)。结论 NR4A3低表达与非小细胞肺癌的发生、发展密切相关,可能参与调节肿瘤干细胞表面抗原CD133表达。Objective To investigate NR4A3 and CD133 expression in non-small cell lung cancer （ NSCLC） and their correlation with the clinical characteristics.Methods NR4A3 and CD133 expression was examined immunohistochemically in NSCLC and para-carcinoma tissues from 84 patients.Results NR4A3 expression was decreased in the tumor specimens com-pared with the control tissues （19.0%vs 90.5%,P〈0.05）,NR4A3 expression was related to tumor differentiation and smoking （P〈0.05）,however,NR4A3 expression was not related to age,sex,tumor size,lymph node metastasis and clinical stage （P〉0.05）.NR4A3 expression was negatively correlated with CD133 expression in NSCLC（γ=-0.369,P〈0.05）.Conclusion The NR4A3 low expression may play an important role in the initiation and development of NSCLC,and regulate cancer stem cellssurface antigen CD133 ＋ expression.

关 键 词：肺癌 NR4A3 肿瘤干细胞 CD133 

分 类 号：R734.2[医药卫生—肿瘤]