CEA、CA125等肿瘤标志物联合检测在肺癌诊断中的价值  

Value of Combined Detection of Tumor Markers Such as CEA and CA125 in the Diagnosis of Lung Cancer

作　　者：李林[1] 王迪进[1] 万轲[1] 徐国辉[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2015年第12期1789-1792,共4页The Practical Journal of Cancer

摘　　要：目的探讨癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)以及鳞状上皮细胞癌相关抗原(SCC)5种肿瘤标志物联合检测在肺癌诊断中的价值。方法随机选择肺癌患者102例、肺良性疾病65例以及同期体检健康者80例作为研究对象。所有研究对象均于空腹抽取5 ml外周静脉血,检测CEA、CA125、CYFRA21-1、NSE和SCC浓度。结果肺癌组患者CEA、CA125、CYFRA21-1、NSE及SCC检测阳性率均显著高于肺良性疾病患者、健康组(P<0.05);5种肿瘤标志物联合检测诊断肺癌的敏感度(91.18%)显著高于CEA、CA125、CYFRA21-1、NSE及SCC单项检测敏感度(42.20%、42.16%、50.00%、36.27%、20.59%)(P<0.05)。结论 CEA、CA125、CYFRA21-1、NSE及SCC在肺癌的临床诊断与分型中均具有一定价值,5项肿瘤标志物的联合检测可以显著提高其敏感性。Objective To study the value of serum carcinoembryonic antigen （ CEA ） , carbohydrate antigen 125 （CA125）,cytokeratin 19 fragments （CYFRA21-1）,neuron-specific enolase （NSE） and squamous cell carcinoma antigen （SCC） in the diagnosis of lung cancer.Methods 102 cases of lung cancer patients,65 cases of lung benign diseases and 80 cases of healthy patients were randomly selected.5ml peripheral venous blood was extracted from every research object and the SCC,NSE, CA125,CYFRA21-1 and CEA were detected.Results The positive rates of SCC,NSE,CA125,CYFRA21-1 and CEA of patients in lung cancer group were significantly higher than those in other 2 groups（P〈0.05）.The sensitivity of 5 tumor markers com-bined detection in the diagnosis of lung cancer （91.18%） was significantly higher than each one of CEA,CA125,CYFRA21-1, NSE and SCC（40.20%,42.16%,50.00%,36.27%,20.59%）（P〈0.05）.Conclusion CEA,CA125,CYFRA21-1,NSE and SCC have certain value in the clinical diagnosis and classification of lung cancer,and the combined detection of the 5 tumor mark-ers can significantly increase the sensitivity.

关 键 词：肺癌 肿瘤标志物 联合检测 

分 类 号：R734.2[医药卫生—肿瘤]