伴有长期吸烟史食管癌患者中VEGF和Ki-67水平的临床意义  

Clinical Significance of VEGF and Ki-67 in Esophageal Cancer Patients with Long-term Smoking History

作　　者：孙小莉[1] 曹晓侠[2] 

机构地区：[1]陕西省宝鸡市妇幼保健院,721000 [2]陕西中医药大学附属医院,712000

出　　处：《实用癌症杂志》2015年第12期1793-1796,共4页The Practical Journal of Cancer

摘　　要：目的检测伴有长期吸烟史的食管癌患者血管内皮细胞生长因子(VEGF)和增殖细胞核抗原Ki-67的水平并探讨其临床意义。方法选取癌变组织标本和血样标本各80例,按性别不同,有无长期吸烟史进行分组并检测VEGF和Ki-67的表达。同时收集同期正常的食管组织和血清标本20例,为对照组。结果 1食管癌患者血清中VEGF的表达水平明显高于正常对照组(P<0.01)。伴有吸烟史的食管癌男性患者比起无吸烟史的男性患者,VEGF的表达水平明显升高(P<0.05);伴有吸烟史的食管癌女性患者血清中VEGF含量明显高于无吸烟史的女性患者(P<0.05);伴长期吸烟史的男性食管癌和女性食管癌组之间,无吸烟史的男性和女性食管癌组之间比较,差异性均不明显(P>0.05)。2Ki-67在食管癌患者癌变组织中阳性表达率明显高于正常对照组(P<0.01)。伴有吸烟史的食管癌男性患者比起无吸烟史的男性患者,整体阳性率无明显差异,但>50%的阳性表达率比较,伴吸烟史的Ki-67的表达水平明显升高(P<0.05);伴有吸烟史的食管癌女性患者比起无吸烟史的女性患者,整体阳性率无明显差异,但>50%的阳性表达率比较,伴吸烟史的Ki-67的表达水平明显升高(P<0.05);伴长期吸烟史的男性食管癌组和女性食管癌组之间,无吸烟史的男性食管癌组和女性食管癌组之间比较,差异性均不明显(P>0.05)。结论癌变的发展程度与VEGF和Ki-67呈正相关的趋势,并且吸烟在食管癌疾病发生和发展中起到重要的作用,尤其在癌变的发展中可明显加快癌变组织的恶化程度。Objective To investigate the clinical significance of VEGF and Ki-67 in esophageal cancer patients with long-term smoking history.Methods 80 cases of canceration tissues and blood samples were grouped according to different gen-der and with or without long-term smoking history,and the expression of VEGF and Ki-67 were detected.20 cases of normal e-sophageal tissue and serum specimens were the control group.Results ①Serum VEGF expression level of esophageal cancer pa-tients was significantly higher than the normal control group（P〈0.01）;the expression of VEGF in men with esophageal cancer with long-term smoking history was higher than without long-term smoking history,the expression of VEGF in women with esopha-geal cancer with long-term smoking history was higher than without long-term smoking history,there had no significant difference among men and women with or without smoking history （P〉0.05）.②Ki-67 in esophageal cancer tissue patients positive expres-sion rate was significantly higher than normal control group（P〈0.01）.Male patients with esophageal cancer with smoking history and without smoking history had no difference in the total positive rate,but 〉50% positive expression rate,expression of Ki-67 levels in male patients with esophageal cancer with smoking history were significantly increased（ P〈0.05） .Female patients with esophageal cancer with smoking history and without smoking history had no difference in the total positive rate,but 〉50%posi-tive expression rate,expression of Ki-67 levels in female patients with esophageal cancer with smoking history were significantly increased（P〈0.05）.There had no significant difference among men and women with or without smoking history （P〉0.05）. Conclusion The degree of carcinogenesis and VEGF and Ki-67 are positively correlated,and smoking played an important role in the occurrence and development of esophageal cancer,the development of carcinogenesis can significantly speed up the degree of deterioration in cancerous tis

关 键 词：长期吸烟史 食管癌 血管内皮生长因子(VEGF) 增殖细胞核抗原Ki-67 

分 类 号：R735.1[医药卫生—肿瘤]