运动疗法与基质细胞衍生因子-1促进脑梗死患者下肢运动功能恢复的研究  

Correlation research on exercise therapy with SDF-1α to promote lower extremity motor function in patients with cerebral infarction

作　　者：邹东华[1,2] 罗进锋 雷斌[1] 何世安[1] 严翼飞[1] 刘新丁 卢华文[1] 杨振 陈莉[2] 

机构地区：[1]解放军第三○三医院老年病科,南宁530021 [2]广西医科大学第一附属医院神经内科

出　　处：《中国临床保健杂志》2015年第6期565-567,共3页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金项目(81560205);广西自然科学基金项目(2012GXNSFAA276028);广西卫生厅医药卫生计划科研项目(Z2012473;Z2012470)

摘　　要：目的探讨运动疗法与基质细胞衍生因子-1(SDF-1α)对促进脑梗死患者下肢运动功能恢复的作用。方法采用随机数字表法将72例脑梗死患者分为脑梗死后非运动组与脑梗后运动组,另选30名健康老人作对照。脑梗死后非运动组患者采取常规治疗;脑梗死后运动组患者在常规治疗的基础上,进行减重步行训练。分别在脑梗死后第1周、第4周、2个月、3个月4个时点检测外周血SDF-1α水平,采用FMA运动量表评估下肢运动功能恢复情况。结果脑梗死运动组患者SDF-1α水平从脑梗死后第4周开始均较脑梗死非运动组高(均P<0.05);脑梗死运动组患者其下肢FMA评分从第4周开始,均明显高于脑梗死非运动组患者(P<0.05)。结论减重步行训练极有可能通过促进SDF-1α的分泌,进而帮助脑梗死后下肢运动功能的恢复。Objective To explore the correlation of exercise therapy and SDF-1A to promote lower extremity motor function recovery in patient with cerebral infarction. Methods Cerebral infarction patients were randomly divided into two groups, non-exercise group and exercise group, beside, to select 30 healthy elderly as control. Patients in non-exercise group took conventional therapy, exercise group patients took the weight support treadmill training based on the conventional therapy. To detect plasma level of SDF-1 a at 4 time-point （1 week ,4-week, 2-month, 3-month） respectively, as well as to evaluate the low extremity motor function recovery by FMA scale. Result Plasma SDF-1 α level in patients with exercise group were higher than that in non-exercise group （ P 〈0. 05 ） ; low extremity FMA score in patients with exercise group were higher than that in non-exercise group from 4-week （ P 〈 0. 05 ）. Conclusion Weight support treadmill training may help the lower extremity motor function recovery by promoting the secretion of SDF-1α.

关 键 词：脑梗死 功能恢复 下肢 运动疗法 趋化因子CXCL12 

分 类 号：R743.33[医药卫生—神经病学与精神病学]