神经干细胞移植治疗脑梗死的临床观察  

Clinical observation of neural stem cells transplantation in the treatment of cerebral infarction

作　　者：张敏[1] 吴世陶[1] 刘磊[1] 赵源征[1] 石磊[1] 郭亚培[1] 崔明[1] 刘恒方[1] 

机构地区：[1]郑州大学第五附属医院,郑州450052

出　　处：《中国实用神经疾病杂志》2015年第22期8-10,共3页Chinese Journal of Practical Nervous Diseases

基　　金：河南省教育厅科学技术研究重点项目(12A320064)

摘　　要：目的观察神经干细胞移植治疗脑梗死的临床疗效。方法将60例脑梗死患者随机分为静脉注射组14例,腰椎穿刺组18例和对照组28例,对照组给予常规治疗;除常规治疗外,静脉注射组经肘静脉输注神经干细胞;腰椎穿刺组通过腰椎穿刺蛛网膜下腔植入神经干细胞。3组治疗前后均行功能独立性量表(FIM)评分。结果治疗前,对照组、静脉注射组、腰椎穿刺组的FIM评分比较差异无统计学意义(P>0.05);治疗后,静脉注射组和腰椎穿刺组与对照组的FIM评分比较差异有统计学意义(P<0.05);治疗后,腰椎穿刺组与静脉穿刺组的FIM评分比较差异有统计学意义(P<0.05)。结论神经干细胞是治疗脑梗死的一种有效方法,尤其是采用腰椎穿刺经蛛网膜下腔注射神经干细胞可明显改善脑梗死患者的预后,提高其生存质量。Objective To observe the clinical effect of neural stem cell transplantation in the treatment of cerebral infarc- tion. Methods 60 cases with cerebral infarction were randomly divided into intravenous injection group （14 cases）, lumbar puncture （18 cases） and control group （28 cases）. Patients in control group were given routine therapy. Blesides routine treat- ment, the intravenous injection group received neural stem cells infusion by elbow vein injections patients in the lumbar punc- ture group were implanted into neural stem cells through the lumbar puncture. The functional independence scale （FIM） of the three groups were performed before and after treatment. Results Before treatment, the FIM scores in the control group, intra- venous injection group and lumbar puncture group showed no statistically significant differences （P〉0.05） ; After treatment, compared with control group, FIM scores in intravenous group and lumbar puncture group revealed statistically significant difference （P〈0. 05）. After treatment, the difference of FIM scores between intravenous group and lumbar puncture group was a statistical significant （P〈0.05）. Conclusion Neural stem cells is an effective method in the treatment of cerebral infarc- tion, especially the application of subaraehnoid cavity injection by lumbar puncture method can significantly improve the prog- nosis of patients with cerebral infarction and enhance their quality of life.

关 键 词：神经干细胞 移植 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]