小剂量阿司匹林引起上消化道出血的多因素分析  

Risk factors for upper gastrointestinal hemorrhage induced by lowdose aspirin

作　　者：潘玉艳[1] 刘广军[1] 徐克群[2] 薛乐宁[2] 

机构地区：[1]江苏省常州市第二人民医院药剂科,213003 [2]江苏省常州市第二人民医院消化内科,213003

出　　处：《临床合理用药杂志》2015年第34期16-18,共3页Chinese Journal of Clinical Rational Drug Use

基　　金：常州市科技局指导性项目(常州四药临床药学研究基金资助项目;No:CY20119020)

摘　　要：目的筛选长期以小剂量阿司匹林治疗致发生上消化道出血的危险因素。方法回顾性分析该院收治的长期接受小剂量阿司匹林治疗预防心脑血管疾病患者250例,其中未出血患者127例,出血患者123例,采用多因素非条件logistic回归模型分析其发生上消化道出血的危险因素。结果经过logistic回归模型分析,年龄、幽门螺杆菌(Hp)阳性、既往曾有溃疡病史、饮酒史、吸烟史及联合用药(按贡献大小)6个变量是长期小剂量阿司匹林治疗患者发生上消化道出血的危险因素。结论对于长期小剂量阿司匹林治疗的患者随着年龄的增加应特别注意其有较高的上消化道出血风险,应根除Hp,戒烟,戒酒,减少危险因素的聚集发生。Objective To screen the risk factors of upper gastrointestinal bleeding caused by small dose aspirin therapy. Methods Retrospectively analyzed long term low-dose aspirin for prevention of cardiovascular disease in patients with cerebral vascular disease in 250 cases,including 127 cases with no bleeding,bleeding in 123 cases,A multiple factor unconditional logistic regression model was employed to analyze the risk factors of long-term low-dose aspirin in treatment upper gastrointestinal hemorrhage. Results According to logistic regression analysis,six risk factors of upper gastrointestinal hemorrhage were as follows,ranged according to their pathogenic importance： age,helicobacter pylon（ Hp） infection,drinking history,smoking history,ulcer history and medicine combination. Conclusion As age increase,people undertaking long-term low-dose aspirin treatment should pay more attention to the risk of upper gastrointestinal hemorrhage. They are advised to eradicate Hp,stop drinking and smoking,avoid medicine combination so as to avoid the aggregation of risk factors.

关 键 词：阿司匹林 上消化道出血 回归分析 LOGISTIC模型 

分 类 号：R573.2[医药卫生—消化系统]