Ⅱ～Ⅲ期NSCLC患者术后辅助化疗依从性分析  

Analysis on the Compliance with Post-operative Adjuvant Chemotherapy in Non-small Cell Lung Cancer Patients

作　　者：梁亦贤 茅乃权[2] 左传田[2] 刘德森[2] 潘琪[2] 杨立[2] 王守峰[2] 谢彤[2] 

机构地区：[1]湖州市第一人民医院胸外科,313000 [2]广西医科大学附属肿瘤医院胸外科,南宁530021

出　　处：《医学研究杂志》2015年第11期118-121,共4页Journal of Medical Research

摘　　要：目的探讨非小细胞肺癌（NSCLC）患者术后辅助化疗依从性的影响因素，以及术后辅助化疗依从性对患者预后的影响。方法回顾性分析109例Ⅱ～Ⅲ期NSCLC患者的临床资料，对可能影响患者术后辅助化疗依从性的临床因素进行单因素分析和多因素Logistic回归分析，并对其中行完全切除的92例NSCLC患者进行随访和生存分析。结果本组术后辅助化疗依从性好的患者仅占28．4％。年龄、文化程度、付费方式、手术方式及化疗不良反应与NSCLC患者术后辅助化疗依从性有关。多因素分析显示年龄、文化程度、付费方式和手术方式是影响患者术后辅助化疗依从性的独立因子。接受完全切除手术的患者术后辅助化疗依从性与预后有关，依从性好的患者生存期长于依从性差的患者。结论NSCLC患者术后辅助化疗的依从性并不理想，应重点对年龄较大、文化程度较低、自费、全肺切除的患者加强宣教，以提高其依从性。Objective To explore the influencing factors of compliance with post - operative adjuvant chemotherapy in non - small cell lung cancer（NSCLC） patients and the impact of compliance with post - operative adjuvant chemotherapy on prognosis. Methods To- tally 109 NSCLC patients with Ⅱ and Ⅲ stage were analyzed retrospectively. The factors which might affect the compliance with post - op- erative adjuvant chemotherapy in NSCLC patients were analyzed by univariate analysis and multivariate logistic regression model. Ninty two cases of completely reseated NSCLC patients were followed up and analyzed by survival analysis. Results In the whole group,good com- pliance with post- operative adjuvant chemotherapy in NSCLC patients was only 28.4%. Age, degree of education, paying way, surgery way and toxicity were related to the compliance with post - operative adjuvant chemotherapy in NSCLC patients. Multivariate logistic re- gression analysis showed that age, degree of education, paying way and the surgery way were the independent influencing factors of compli- ance with post - operative adjuvant chemotherapy in NSCLC patients. For NSCLC patients who accepted completely resection, the compli- ance with post- operative adjuvant chemotherapy was related to prognosis,patients with good compliance had a longer survival time than patients with poor compliance. Conclusion The compliance with post - operative adjuvant chemotherapy in NSCLC patients is unsatisfac- tory. In order to improve the compliance, the patients who are elder, with low cultural level, at their own expense, accept pneumonectomy should be strengthen the propaganda and education.

关 键 词：非小细胞肺癌 辅助化疗 依从性 预后 

分 类 号：R734.2[医药卫生—肿瘤]