血清IGF-1、bFGF及VEGF浓度与早产儿视网膜病的关系  

Changes and Significance of Serum IGF-1,bFGF and VEGF Levels in Premature ROP Infants

作　　者：郑靖阳 肖秀漫[2] 陈清 林锋 瞿尔力 

机构地区：[1]温州市中心医院新生儿科,325027 [2]温州医科大学附属育英儿童医院新生儿科,325027

出　　处：《医学研究杂志》2015年第11期153-156,共4页Journal of Medical Research

基　　金：温州市科技局基金资助项目(Y20120078);温州市卫生局基金资助项目(2010A004)

摘　　要：目的研究血清中胰岛素样生长因子-1（insulin-likegrowthfactor-1，IGF-1）、碱性成纤维细胞生长因子（basicfihrohlastgrowthfactor，bFGF）及血管内皮生长因子（vascularendothelialgrowthfactor，VEGF）与早产儿视网膜病（retinopathyofpre—maturity，ROP）的关系，探讨其可否作为ROP的预测指数，协助诊断ROP。方法胎龄≤31周和（或）体重≤1500g的早产儿进行间接眼底镜筛查，根据ROP国际分类法诊断为ROP的患儿为实验组，其中根据严重程度分为ROPⅠ-Ⅳ期；对照组：与ROP组胎龄、出生体重相匹配的同期住院非ROP早产儿。对所有研究对象在生后1周或纠正胎龄31周时取静脉血2ml，采用ELISA法检测血清中IGF-1、bFGF及VEGF浓度。结果入选的早产儿ROP组48例，对照组50例。ROP组血清中IGF-1、bFGF及VEGF浓度显著低于对照组（P均〈0．001）。ROC曲线分析发现，IGF-1具有最好的预测和诊断价值，而bFGF、VEGF次之。结论≤31周和（或）出生体重≤1500g的早产儿在其生后第1周或纠正胎龄31周时取血，若出现IGF-1明显降低（〈28．08ng／ml），同时伴有bFGF（〈320．65ng／L）及VEGF（〈232．89ng／L）的降低，则预示ROP的发生率增加。Objective To observe the changes of serum IGF - 1, bFGF and VEGF levels in premature infants, and to discuss the predicting values for the development of ROP. Methods Preterm infants admitted into Wenzhou central hospital and Yuying children＇s Hospital of Wenzhou Medical University from May 2010 to May 2013 were chosen according to those whose birth weight （BW） ≤ 1500g and （or） gestational age （GA） ≤31 weeks joined in ROP -screen, and those who were diagnosed as ROP according to ICROP were in- cluded into ROP group. In the same time, those who didn＇t develop ROP were divided into control group. Their gestational age were not different with ROP group. Serum IGF - 1 , bFGF and VEGF were measured one week from their birth or correct gestational age of 31 weeks. Serum IGF - 1 ,bFGF and VEGF were evaluated with ELISA method. Results Forty eight of them developed ROP. Those all were stage Ⅰ-Ⅳ ROP. Fifty of them who didn＇t develop ROP were divided into control group. The concentration of IGF - 1 ,bFGF and VEGF in serum of Group ROP were all significantly lower than the control group. （all P 〈 0. 001 ）. ROC curves showed that the area under ROC curve of IGF - 1 was 0. 902, more than bFGF（0. 896） and VEGF（0. 884）. Conclusion The low serum IGF - 1 （ 〈 28.08ng/ml） , bFGF （ 〈 320.65ng/L）and VEGF（ 〈 232.89ng/L） of a premature in the first week or correct gestational age of 31 weeks and （or）BW ≤ 1500g would probably suggest the development of ROP.

关 键 词：早产儿视网膜病 碱性成纤维细胞生长因子 胰岛素样生长因子-1 血管内皮生长因子 酶联免疫吸附试验 

分 类 号：R774[医药卫生—眼科]