趋化因子受体7联合CT诊断膀胱移行细胞癌淋巴结转移  

Chemokine receptor CCR7 as a predictive biomarker associated with computed tomography in diagnosing lymph node metastasis of bladder carcinoma

作　　者：谢文杰[1] 祖雄兵[1] 陈金波[1] 崔宇[1] 唐云华[1] 李超[1] 刘龙飞[1] 

机构地区：[1]中南大学湘雅医院泌尿外科,湖南长沙410008

出　　处：《中国现代医学杂志》2015年第33期32-35,共4页China Journal of Modern Medicine

摘　　要：目的研究膀胱移行细胞癌(BTCC)中趋化因子受体7(CCR7)的表达,并联合CT诊断淋巴结转移。方法研究该院行根治性膀胱全切+盆腔淋巴结清扫的115例病例,术前行泌尿系及盆腔CT扫描,膀胱癌组织标本行CCR7免疫组织化学染色并记录盆腔淋巴结转移情况。运用统计学方法分析CCR7的表达与淋巴结转移的关系,并比较分析CCR7、CT及CCR7联合CT诊断膀胱癌淋巴结转移的敏感性、特异性和精确度。结果 BTCC组织中的CCR7表达与淋巴结转移相关(P<0.05)。多因素分析显示CCR7的表达是膀胱癌淋巴结转移的独立影响因子(P<0.05)。采用CT诊断淋巴结转移的敏感性、特异性和精确度分别为52.4%、79.5%及69.6%,而CCR7联合CT诊断淋巴结转移的敏感性、特异性和精确度分别为92.3%、83.6%及70.0%。结论 CCR7是膀胱癌淋巴结转移的独立影响因子,CCR7联合CT可提高CT诊断淋巴结转移的敏感性。[Objective] To determine whether chemokine receptor CCR7 expression combined with com- puted tomography （CT） has a relationship with lymph node metastasis in bladder transitional cell carcinoma （BTCC）. [Methods] Totally 115 BTCC cases were studied in our department. Preoperative CT scans of ab- domen and pelvis, CCR7 immunohistochemical expression in tumor specimens and pathological findings for lymph node metastasis were assessed. The sensitivity, specificity and accuracy of CCR7, CT and their combi- nation in diagnosis of lymph node metastasis of BTCC were evaluated. [Results] The CCR7 expression in BTCC was correlated with lymph node metastasis （P〈 0.05）. Multivariate analysis indicated that CCR7 expres- sion was an independent predictor for lymph node metastasis in BTCC （P 〈 0.05）. The sensitivity, specificity and accuracy of CCR7 combined with CT scan in the diagnosis of lymph node metastasis of BTCC were 92.3%, 83.6% and 70.0%, respectively; those of CT alone were 52.4%, 79.5% and 69.6%, respectively. [Conclusions] CCR7 is an independent indicator for lymph node metastasis of BTCC. CCR7 combined with CT can improve the sensitivity of CT in diagnosing lymph node metastasis in BTCC.

关 键 词：CCR7 膀胱癌 CT 淋巴结转移 

分 类 号：R737.14[医药卫生—肿瘤]