乳腺导管原位癌超声征象及其与Her-2、Ki-67表达的相关性  

Analysis of the correlation between ultrasonographic signs and expression of Ki-67 and Her-2 in breast ductal carcinoma in situ

作　　者：袁美芹 郭坤霞[1] 

机构地区：[1]新疆石河子大学医学院第一附属医院功能科,新疆维吾尔自治区石河子市832008

出　　处：《临床超声医学杂志》2015年第11期770-771,共2页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨乳腺导管原位癌(DCIS)的超声表现及其与Her-2、Ki-67表达之间的关系。方法将56例DCIS患者根据超声表现分为非肿块组(20例)和肿块组(36例),并比较两组声像图特征与Her-2、Ki-67表达的相关性。结果肿块组的DCIS患者Ki-67阳性表达率为41.7%(15/36),非肿块组为70.0%(14/20),差异有统计学意义(P<0.05)。肿块组的DCIS患者Her-2阳性表达率为63.9%(23/36),非肿块组为65.0%(13/20),差异无统计学意义。结论超声图像中非肿块组的DCIS患者其Ki-67阳性表达较肿块组多,间接提示病灶分化程度较低、预后不良。Objective To explore the relationship between ultrasonographic signs and expression of Ki-67,Her-2 in breast ductal carcinoma in situ（DCIS）.Methods Fifty-six cases of DCIS were divided into mass group（36 cases）and non-mass group（20 cases） to detect the correlation between ultrasonographic characteristics with the expression of Her- 2,Ki- 67.Results In non-mass group,70.0%（14/20）were Ki-67 posotive. In mass group,41.7%（15/36）were Ki-67 posotive. Ki-67 positive rate of the two groups was statistically different（P〈0.05）.However Her-2 positive in mass group was 63.9%（23/36）and in non-mass group was 65.0%（13/20）,Her-2 positive rate of the two groups was not statistically significant.Conclusion Positive Ki-67 is more common in non-mass group than in mass group. Sonographic non-mass indicated poorly differentiated and indicators of poor prognosis.

关 键 词：乳腺导管原位癌 超声表现 KI-67 HER-2基因 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]