上皮性卵巢癌组织中HE4和CD133的表达及临床意义  

Expression and clinical significance of TH4 and CD133 in epithelial ovarian cancer

作　　者：陆冬梅[1] 杨俊红[1] 

机构地区：[1]河北省唐山市妇幼保健院妇产科,063000

出　　处：《河北医药》2015年第23期3538-3540,共3页Hebei Medical Journal

摘　　要：目的探讨人附睾蛋白HE4和CD133在上皮性卵巢癌中的表达及临床意义。方法收集病理标本采用免疫组化法检测上皮性卵巢癌组织(n=57)及正常卵巢组织(n=19)HE4和CD133的表达情况。分别研究HE4和CD133与各临床病理参数的关系并进行相关性分析。结果 HE4在正常卵巢组和上皮性卵巢癌组中阳性表达率分别为42.1%(8/19)、71.9%(41/57),CD133在2组中阳性表达率分别为31.6%(6/19)、68.4%(34/57),差异有统计学意义(P<0.05)。HE4和CD133的表达均与临床病理分期、组织分化程度、绝经状态和淋巴结转移有显著相关性(P<0.05)。Spearman相关性分析显示HE4表达与CD133的表达有相关性(r=0.340,P=0.006)。结论 HE4和CD133的高表达可能与上皮性卵巢癌的发生、发展有一定关系。Objective To explore the expression and clinical significance of HE4 and CD133 in epithelial ovarian cancer（ EOC）. Methods The expression levels of HE4 and CD133 protein were detected in 57 cases of EOC tissues（ EOC group） and 19 cases of normal ovarian tissues（ control group） by immunohistochemistry. The correlation between the expressions of TH4,CD133 and clinicopathological parameters was analyzed. Results The positive expression rates of HE4 in control group and in EOC group were 42. 1%（ 8 /19）,71. 9%（ 41 /57）,respectively,and the positive expression rates of CD133 in the two groups were 31. 6%（ 6 /19）,68. 4%（ 34 /57）,respectively,there were significant differences between two groups（ P 〈0. 05）. The expressions of HE4 and CD133 were closely correlated to clinical pathological staging,histodifferentiation degree,menopausal state,lymph node metastasis（ P 〈0. 05）. Spearman correlation analysis showed that the expression of HE4 was closely related to that of CD133（ r = 0. 340,P 〈0. 01）. Conclusion The overexpression of HE4 and CD133 protein may be correlated to the pathogenesis and development of EOC.

关 键 词：上皮性卵巢癌 HE4 CD133 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]