宫颈鳞癌预后影响因素的临床研究  

The influencing factors on prognosis of squamous carcinoma of the cervix

作　　者：辛华栋[1] 

机构地区：[1]河北省邯郸市第一医院,056002

出　　处：《河北医药》2015年第24期3698-3702,共5页Hebei Medical Journal

摘　　要：目的回顾性研究77例宫颈鳞癌患者临床病理特征及环氧合酶-2(cyclooxygenase-2,COX-2)对其预后的影响。方法收集并分析77例宫颈原发鳞癌患者的临床资料,并采用免疫组化SP法,在石蜡标本中检测COX-2蛋白的表达情况,探讨宫颈癌的预后影响因素。结果 5年总生存率(overall survival rate,OS)为74.03%(57/77)。生存分析显示:组织学分级、临床分期、淋巴结转移、宫旁浸润或脉管瘤栓、肌层浸润深度及COX-2对宫颈鳞癌预后的影响差异有统计学意义(P<0.05)。结论组织学分级、临床分期、淋巴结转移、宫旁浸润或脉管瘤栓及肌层浸润深度及COX-2是宫颈鳞癌的独立预后因素。Objective To study retrospectively clinicopathological characteristics of patients with squamous carcinoma of the cervix and the effects of cyclooxygenase-2 （COX-2） on patients＇ prognosis. Methods The clinical data about 77 cases of primary squamous carcinoma of cervix were collected and analyzed, moreover, the expression levels of COX-2 protein were detected by immunohistoehemistry （SP） to explore the influencing factors on prognosis of squamous carcinoma of the cervix. Results The 5-year overall survival rate was 74.03 % （57/77）. The survival analysis showed that histological grades, clinical staging,lymph node metastasis, latero-uterus infiltration, vessel tumor embolus, muscular-invasive depth and COX-2 affected significantly the prognosis of patients with squamous carcinoma of the cervix （ P 〈 0.05 ）. Conclusion The histological grades, clinical staging, lymph node metastasis, latero-uterus infiltration, vessel tumor embolus, muscular-invasive depth and COX-2 are independent prognostic factors of squamous carcinoma of the cervix.

关 键 词：宫颈鳞状细胞癌 环氧合酶-2 预后 

分 类 号：R737.33[医药卫生—肿瘤]