蛋白激酶D:新的肿瘤调控因子  

Protein kinase D: a new regulator of tumor

作　　者：韩玮[1] 韩明志[2] 

机构地区：[1]济宁市第一人民医院神经内科,山东省272000 [2]山东大学齐鲁医院神经外科,济南250012

出　　处：《中华脑科疾病与康复杂志（电子版）》2015年第5期67-70,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：山东大学科技创新基金(2012389);山东大学齐鲁医学班科技创新基金(M2011e01)

摘　　要：蛋白激酶D(PKD)是丝氨酸/苏氨酸蛋白激酶家族中的一类新成员,参与调控了细胞生理以及病理状态的众多功能,近年来受到广泛关注。已有文献报道,PKD特定蛋白亚型的异常表达在多类肿瘤的发生、发展中起到关键作用,影响肿瘤细胞的增殖、分化、凋亡、侵袭以及上皮间充质样变等过程。本文通过介绍PKD的结构、活性调控机制及其相关信号通路,对近年来PKD在肿瘤中的研究进展进行综述。Protein kinase D （PKD） is a novel family of serine/threonine kinases that has been widely studied in recent years. PKD is a crucial protein that regulates various functions within the cell and widely involved in the process of pathological cellular state. It has been proved that aberrant expression of PKD is associated with enhanced cancer phenotypes, such as cell proliferation, survival, invasion, and epithelial mesenchymal transition. In this review, we summarized the structural and functional aspects of PKD and highlight the pathobiological roles of PKD in cancer.

关 键 词：蛋白激酶类 细胞增殖 肿瘤侵润 信号通路 

分 类 号：R730.2[医药卫生—肿瘤]