头颈部鳞癌中α-catulin表达的临床病理和预后意义  

The Clinicopathological and Prognostic Significance of α-catulin Expression in Head Neck Squamous Cell Cancers

作　　者：邱波[1] 张卓[2] 申道福 杨雪峰[3] 郑华川[3] 高野康雄 黄克强[1] 

机构地区：[1]辽宁医学院附属第二医院口腔科,辽宁锦州121001 [2]辽宁医学院附属第一医院口腔科,辽宁锦州121001 [3]辽宁医学院附属第一医院肿瘤中心,辽宁锦州121001 [4]日本神奈川癌中心

出　　处：《中国医科大学学报》2015年第12期1079-1082,1086,共5页Journal of China Medical University

基　　金：国家自然科学基金(81172371;81472544);辽宁省教育厅优秀人才计划(LJQ2014093);辽宁省科技计划项目(2015408001);辽宁省自然科学基金(2015020326)

摘　　要：目的细胞骨架连接蛋白α-catulin是Rho信号通路组件之一,在癌细胞凋亡、抗衰老、细胞骨架重组、迁移、侵袭和上皮细胞间质转化(EMT)过程中发挥重要作用。探讨头颈部鳞癌中α-catulin表达的临床病理和预后意义。方法采用免疫组化方法检测α-catulin在头颈部鳞状上皮癌(HNSCC)组织芯片中的表达,分析其和临床病理学特征及生存率的关系。结果α-catulin在HNSCC原发癌中的表达比正常和异型增生的鳞状上皮细胞显著增高(P<0.05),但是和HNSCC的恶性生物学行为和不良预后无明显相关(P>0.05)。Cox比例风险回归分析结果显示远处转移和TNM分期是HNSCC的独立预后因素(P<0.05)。结论上调α-catulin的表达在HNSCC病因学上具有重要意义,可作为研究HNSCC肿瘤发生的分子靶标。Objective Rho signaling component α-catttlin, is a cytoskeletal linker protein and plays an important role in apoptotic and senescence resistance, cytoskeletal reorganization, mobility, invasion and epithelial to mesenchymal transition （EMT） of cancer cells. Methods Here, we ex- amined α-catulin expression in squamous epithelium, dysplasia and cancer of head and neck on tissue microarmys by immunostaining. Its expres- sion was compared with clinicopathological parameters and survival rate of cancers. Results It was found that α-catulin expression level was signifi- candy higher in primary cancers than that in normal squamous epithelium and dysplasia （P 〈 0.05 ）, but not significantly correlated with aggressive behaviors or adverse prognosis of HNSCC patients （P 〉 0.05）. Cox＇ s proportional hazard model indicated that distant metastasis and TNM staging were independent prognostic factors for overall survival of the patients with head and neck squamous carcinoma （HNSCC, P 〈 0.05 ）. Conclusion These findings suggested that up-regulated expression of α-catulin protein may play an important role in the pathogenesis of HNSCC, which might be employed as a potential marker for tumorgenesis of HNSCCs.

关 键 词：头颈部鳞癌 α-catulin 肿瘤发生 病理生物学行为 预后 

分 类 号：R739[医药卫生—肿瘤]