响应面法优化番石榴幼果提取液粉末原料喷雾干燥工艺  

Optimization of Spray Drying Process of Powder from the Raw Fruits Extracts of Psidium guajava by Response Surface Method

作　　者：苏丹[1] 谢果[1] 刘文利[1] 吴敏芝[1] 

机构地区：[1]电子科技大学中山学院化学与生物工程学院,广东中山528402

出　　处：《中国药房》2015年第34期4840-4843,共4页China Pharmacy

基　　金：广东省中山市科技计划项目(No.2013A3FC0269;20123A276)

摘　　要：目的:优选番石榴幼果提取液的喷雾干燥工艺条件。方法:以得率为指标,基于单因素试验对番石榴幼果提取液的进样质量浓度、进样温度、进样速度3个因素采用响应面法优化喷雾干燥工艺条件;同时考察了总黄酮和总多酚在各工艺步骤中的含量和转移率。结果:最优工艺条件为进样质量浓度100 g/L、进样温度170℃、进样速度180 ml/h;验证试验显示3批产品得率为(56.08±0.58)%(RSD=1.04%,n=3),试验值与预测均值差值为0.25,无显著性差异(P>0.05);喷干粉中保留了较高的总黄酮和总多酚,二者质量分数分别为(17.80±0.09)%和(1.23±0.06)%,工艺转移率分别为87.7%、25.7%。结论:优化的工艺可行,所得产品合格,可用于进一步制备多种固物制剂。OBJECTIVE：To optimize spray drying process for the raw fruits extract of Psidium guajava. METHODS：Based on single factor,the response surface method was designed to optimize spray drying process condition,using extract rate as index and mass concentration,sampling temperature and sampling speed as factors. The contents and transport rate of total flavones and total polyphenol were determined in each step. RESULTS：The optimal process was as follows as mass concentration of 100 g/L,sampling temperature of 170 ℃,sampling speed of 180 ml/h. Under this condition,the yield of 3 batches of product was（56.08±0.58）%（RSD=1.04%,n=3）. The difference value between test value and predict value was 0.25,without significant difference（P0.05）. The powder of the raw fruits of P. guajava had high contents of total flavones [（17.80±0.09）%] and total polyphenol[（1.23±0.06）%]. The transport rates of them were 87.7% and 25.7%. CONCLUSIONS：Optimized process is feasible to obtain qualified product,and can be used to make medicinal solid preparation.

关 键 词：番石榴 幼果 提取液 喷雾干燥 工艺优化 响应面法 总黄酮 总多酚 

分 类 号：R283[医药卫生—中药学]