NLRP3炎症小体在脑缺血再灌注损伤中的作用  

Effects of NLRP3 inflammasome on cerebral ischemia-reperfusion injury

作　　者：高丽[1,2] 沈沸[1,2] 李焰生[1,2] 

机构地区：[1]上海交通大学医学院附属仁济医院南院神经内科,上海201112 [2]上海交通大学医学院附属仁济医院神经内科,上海200127

出　　处：《上海交通大学学报（医学版）》2015年第12期1896-1899,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海交通大学医学院附属仁济医院科研种子基金培养计划(RJZZ-14-018)~~

摘　　要：缺血再灌注损伤是一个涉及多种因素相互作用的炎症级联反应过程。近年来,众多研究表明,NLRP3炎症小体作为先天免疫重要的模式识别受体参与了缺血再灌注的炎症损伤,阻断或抑制NLRP3的活化可能成为缺血性脑血管病新的治疗靶点。然而,NLRP3在脑缺血发生发展过程中的作用机制还不清楚,该文就NLRP3炎症小体在脑缺血再灌注损伤中的作用与意义作一综述。Ischemia-reperfusion injury is an inflammatory cascade process involving the interaction of multiple factors.In recent years,numerous studies have shown that as an important pattern recognition receptor of innate immune,NLRP3 inflammasome involves in the inflammatory injury of cerebral ischemia-reperfusion.Thus blockage or inhibition of the activation of NLRP3 may be a new therapeutic target for the treatment of ischemic cerebrovascular diseases.However,the mechanisms of NLRP3 during the occurrence and development of cerebral ischemia are still unclear.This paper reviews the role and significance of NLRP3 inflammasome in cerebral ischemia-reperfusion injury.

关 键 词：脑缺血 NLRP3炎症小体 缺血再灌注损伤 

分 类 号：R743.31[医药卫生—神经病学与精神病学]