异甘草酸镁对酒精性肝炎患者TNF和IL-6的影响  

The change of serum TNF and IL-6 levels in alcoholic hepatitis treated by Magnesium isoglycyrrhizinate

作　　者：李伟伟[1] 韩红波[2] 

机构地区：[1]河南科技大学第二附属医院消化内科,洛阳471000 [2]河南科技大学医学院病理及病理生理教研室,洛阳471000

出　　处：《中国当代医药》2015年第33期83-85,共3页China Modern Medicine

摘　　要：目的观察异甘草酸镁对于酒精性肝炎患者的疗效及对TNF和IL-6的影响。方法选择我院2012年3月-2014年3月期间收治的酒精性肝炎患者36例,完全随机分为研究组（18例）和对照组（18例）,研究组给予异甘草酸镁注射液150 mg溶于10%葡萄糖溶液250 ml,1次/d静脉滴注。对照组予以应用硫普罗宁0.2 g溶于10%葡萄糖溶液250 ml,1次/d静脉滴注,治疗时间3周。结果研究组治疗后ALT、AST、GGT、TBi L水平均低于对照组,差异有统计学意义（P〈0.05）。研究组TNF和IL-6水平在治疗前后下降明显,与对照组相比,差异有统计学意义（P〈0.05）。结论异甘草酸镁可降低酒精性肝炎患者TNF和IL-6水平,从而改善肝功能,优于硫普罗宁。Objective To observe the effect of magnesium isoglycyrrhizinate for alcoholic hepatitis patients and the change of serum TNF and IL-6 after the treatment. Methods 36 patients with alcoholic hepatitis in our hospital selected from March 2012 to March 2014 period,were randomly divided into treatment group（18 cases） and control group（18 cases）.Patients in the treatment group were given magnesium isoglycyrrhizinate 150 mg.Patients in the control group was given tiopronin 0.2 g once everyday.The therapy course lasted for 3 weeks. Results After treatment, the levels of ALT,adeclined significantly in the treatment group than that control group,the difference was statistically significant（P〈0.05）.After treatment,the levels of TNF and IL-6,decreased significantly in the treatment group than that control group,the difference was statistically significant（P〈0.05）. Conclusion Magnesium isoglycyrrhizinate can reduced activity of the alcoholic hepatitis and is a more effective than Tiopronin.

关 键 词：酒精性肝炎 异甘草酸镁 TNF IL-6 

分 类 号：R575.1[医药卫生—消化系统]