抗肿瘤靶点PARP-1及其抑制剂的研究进展  

Progress in Research of Inhibitors Targeting PARP-1 for Cancer Therapy

作　　者：谢怡悦 石天晨 王璐莹[1] 徐晓伟[1] 李阳辉[1] 林克江[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《药学进展》2015年第10期761-774,共14页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81573348)

摘　　要：聚二磷酸腺苷核糖聚合酶-1(PARP-1)参与DNA损伤修复,是近年来肿瘤治疗领域的热门靶点。从PARP-1的结构和作用机制出发,综述PARP-1抑制剂的主要结构类型及优化思路,展望其应用前景和亟需解决的问题。Poly（ADP-ribose） polymerase-1 （PARP-1） plays an important role in repairing DNA damage and represents a currently important target in cancer therapy. Based on the structure and mechanism of PARP-1, the major structure types of PARP-1 inhibitors and optimization strategies were reviewed, along with ,an outlook on their future applications and urgent problems to be solved.

关 键 词：PARP-1 抑制剂 肿瘤 

分 类 号：R96[医药卫生—药理学]