柠檬苦素类似物的生物活性和构效关系研究进展  

Research Progress in Biological Activity and Structure-activity Relationship of Limonoids

作　　者：韩学青[1,2] 朱启华[1] 王少驰[1] 徐云根[1,2] 

机构地区：[1]中国药科大学天然药物活性组分与药效国家重点实验室,江苏南京210009 [2]中国药科大学药物化学教研室,江苏南京210009

出　　处：《药学进展》2015年第10期775-780,共6页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.21472242);"重大新药创制"国家科技重大专项(2015ZX09102001)

摘　　要：柠檬苦素类似物是一类高度氧化的四环三萜类植物次生代谢产物,具有镇痛、抗炎、抗肿瘤、昆虫拒食等多种生物活性。对柠檬苦素类似物的结构特点和生物活性进行综述,归纳其构效关系,为该类化合物的进一步结构修饰和改造提供参考。Limonoids, typical secondary metabolites in plants, are highly oxygenated tetranortripenoid with a wide range of biological activities, including but not limited to analgesic, anti-inflammatory, antitumor and insect antifeedant activity. Structure characteristics, bioactivities, and structure-activity relationship of limonoids have been reviewed in this article to provide references for further structural modification of these compounds.

关 键 词：柠檬苦素类似物 生物活性 构效关系 结构修饰 

分 类 号：R914[医药卫生—药物化学]