艾迪注射液联合热疗在老年中晚期食管癌放疗中的疗效及生活质量观察  

Effect of Addie Injection Combined with Hyperthermia in the Treatment of Esophageal Carcinoma in Elderly Patients with Advanced Esophageal Carcinoma

作　　者：吴陈宾 吴金通[1] 彭俊英[1] 丁金琴[1] 丁纪涛 

机构地区：[1]南京军区福州总医院九五临床部,福建莆田351100

出　　处：《辽宁中医药大学学报》2015年第12期135-138,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探究艾迪注射液联合体外高频热疗在老年中晚期食管癌三维适形调强放疗中的疗效及对生活质量的影响。方法:将180例中晚期食管癌老年患者按随机数字法分为3组各60例,A组艾迪注射液联合体外高频热疗与三维适形调强放疗同步、B组体外高频热疗与放疗同步、C组仅行放疗作为对照,观察治疗结束后的近期疗效、生活质量KPS评分,观察治疗期间的毒副反应,治疗结束后对3组病例随访,计算1、2、3年的生存率。结果:A组、B组、C组的总有效率分别为86.67%、75.0%、68.33%,A组总有效率显著高于B组与C组(P<0.05),B组总有效率显著高于C组(P<0.05);A组KPS评分(86.42±10.53)分显著高于B组(75.13±11.21)分与C组(69.27±10.93)分(P<0.05),B组KPS评分显著高于C组(P<0.05);A组总体毒副反应发生率显著低于B组与C组(P<0.05),B组与C组相比较,毒副反应的发生情况无显著差异(P>0.05);A组的1年、2年、3年生存率均显著高于B组与C组(P<0.05),B组的生存率均高于C组,两组1年、2年生存率差异不显著,3年生存率则有显著差异(P<0.05)。结论:在老年中晚期食管癌的治疗中,体外高频热疗与三维适形调强放疗配合应用有协同的抗肿瘤作用,较单纯放疗有较好的疗效,艾迪注射液与体外高频热疗以及三维适形调强治疗联合应用较热疗联合放疗、单纯放疗的疗效更高,且显著降低了毒副反应,明显改善了患者的生活质量、延长了生存期。Objective：To explore the effect of high frequency hyperthermia combined with external high frequency hyperthermia in the treatment of elderly patients with advanced esophageal carcinoma in elderly patients with advanced esophageal carcinoma and the effect on the quality of life. Methods：180 patients with advanced esophageal carcinoma were randomly divided into three groups,60 cases in each group.A group Addie injection combined with high frequency hyperthermia and three-dimensional conformal radiotherapy synchronous,B group in vitro high frequency hyperthermia combined with radiotherapy,C group was treated as the control group. The clinical efficacy,quality of life and KPS score,the side effects of the treatment were observed,After treatment,three groups of patients were followed up for 1 years,2 years,3 years of survival rate. Results：The total effective rate of A group,B group and C group were 86.67%,75% and 68.33% respectively,A group was significantly higher than that of B group and C group（P〈0.05）,and the B group was significantly higher than that in group C（P〈0.05）;The KPS score in A group（69.27±10.93）was significantly higher than that in B group（69.27±10.93）and C group（69.27±10.93）（P〈0.05）,and the KPS score was significantly higher in B group than in C group（P〈0.05）. The 1 year,2 year and 3 year survival rates in A group were significantly higher than those in B group and C group（P〈0.05）,and the survival rate of B group was higher than that in C group,while 1 years,2 years,two years survival rate was not significant,and the 3 year survival rate was significantly different（P〈0.05）. Conclusion：in the treatment of elderly patients with esophageal cancer,high frequency hyperthermia combined with three-dimensional conformal radiation therapy has better effect than simple radiotherapy. Addie injection combined with hyperthermia combined with hyperthermia combined with radiotherapy and radiotherapy alone is more effective,and has significantly improved th

关 键 词：食管癌 三维适形调强放疗 体外高频热疗 艾迪注射液 

分 类 号：R73[医药卫生—肿瘤]