偏头痛患者MRI亚临床病变的特点  

Clinical study of subclinical lesions in patients with migraine

作　　者：刘彬[1,2] 汪国胜[1,2] 钟平[1,2] 年夫顺[1,2] 张尊胜[3] 

机构地区：[1]安徽省宿州市立医院神经内科,234000 [2]安徽医科大学宿州临床学院神经内科,安徽宿州234000 [3]徐州医学院附属医院神经内科,江苏徐州221006

出　　处：《蚌埠医学院学报》2015年第11期1500-1502,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨偏头痛患者MRI亚临床病变的特点。方法:对偏头痛患者(偏头痛组)59例和健康体检正常者(对照组)33名行头颅MRI检查,观察亚临床病变的声像图特点。根据头颅MRI结果分为有亚临床病变偏头痛组和无亚临床病变偏头痛组,2组在头痛发作期及发作间期均行血清神经元特异性烯醇化酶测定。结果:偏头痛组有16例患者头颅MRI显示亚临床病变,病变分布在额叶12例、顶叶8例、基底核区6例、半卵圆中心5例、枕叶2例、侧脑室前角1例、脑干1例,患病率为27.12%,高于对照组的6.06%(P<0.05)。与无亚临床病变偏头痛组比较,有亚临床病变偏头痛组发作期及发作间期血清神经元特异性烯醇化酶水平均升高(P<0.05)。结论:偏头痛患者发生亚临床脑损伤的危险性增加,其亚临床病变主要分布于额叶及顶叶,这说明偏头痛可能是一种隐袭的、缓慢性发展的疾病。Objective： To explore the features of subclinical lesions in patients with migraine. Methods： Brain magnetic resonance images were performed to 59 migraineurs（ migraine group） and 33 normal subjects（ control group）,and the features of subclinical brain lesions were observed. According to the MRI results,the migraine patients were divided into subclinical-brain-lesion group and nonsubclinical-brain-lesion group; the serum levels of neuron-specific enolase of the two groups were measured during a migraine attack and attack-free period. Results： Subclinical brain lesions were observed in 16 patients with migraine. Anatomically the lesions were distributed as follows： 12 in the frontal lobe,8 in the parietal,6 in the basal ganglia,5 in the semioval center,2 in the occipital lobe,1 in the anterior horn of the lateral ventricle and 1 in the brain stem. Migraineurs had a higher prevalence of subclinical brain lesions than the control（ 27. 12% vs 6. 06%）（ P〈0. 05）. The ictal and interictal serum neuron-specific enolase levels of the migraineurs with subclinical brain lesions were significantly higher than those of the migraineurs without subclinical brain lesions（ P〈0. 05）.Conclusions： Subclinical brain lesions are mainly located in the frontal and parietal lobe. Patients with migraine might be associated with an increased risk of subclinical brain lesions,which indicates that migraine might be an insidious,slow development disease.

关 键 词：偏头痛 亚临床病变 神经元损伤 神经元特异性烯醇化酶 

分 类 号：R747.2[医药卫生—神经病学与精神病学]