阿司匹林对小鼠腹水型肝癌H_(22)的作用研究  

Effect of Aspirin on Mice Liver Cancer

作　　者：林增榕 

机构地区：[1]福建医科大学附属协和医院病案室,福州350001

出　　处：《海峡药学》2015年第11期20-22,共3页Strait Pharmaceutical Journal

摘　　要：目的研究阿司匹林对小鼠腹水型肝癌(H_(22))瘤株的体内外抑制作用。方法采用四甲基偶氮唑蓝(MTT)法检测阿司匹林对H_(22)细胞生长的抑制作用,并描绘量效曲线图。建立肝癌H_(22)细胞移植瘤模型并进行体内实验,观察尾静脉给予阿司匹林后体内抗癌效果。结果阿司匹林对小鼠肝癌H_(22)细胞具备增殖抑制作用并表现出明显的剂量依赖性;同时,阿司匹林对肝癌H_(22)细胞实体移植瘤模型具备体内抗癌作用。200mg/(kg·d)尾静脉给药,抑瘤率达40.11%。结论阿司匹林对小鼠腹水型肝癌H_(22)体内外均有抑制作用。OBJECTIVE To study the inhibitory effect of aspirin on mice liver cancer （ H22 ） in vitro and in vivo. METHODS The growth inhibition effect of aspirin in mice liver cancer （ H22 ） ceils was examined by MrFF method. The model of H：2 cell transplantation tumor was established and experimeated in vivo, the effect of anti tumor was observed. RESULTS Aspirin can inhibit the proliferation of H22 cells with obvious dose-dependent and timedependent manner. Meanwhile aspirin can inhibit mice liver cancer H22 cells transplantation tumor in vivo. After 200mg/（ kg · d） aspirin treatment by tail vein injection, inhibitory rate was 40. 11%. CONCLUSION Aspirin has inhibitory effect on mice liver cancer H22 in vitro and in vivo.

关 键 词：阿司匹林 肝癌 H22 

分 类 号：R73-36[医药卫生—肿瘤]