扬州地区4422例女性人乳头瘤病毒感染调查分析  

Analysis on the investigation of human papilloma virus infection in 4422 women in Yangzhou region

作　　者：程文国[1] 李炜[1] 李莹莹[1] 成颖[1] 刘艳[1] 

机构地区：[1]扬州市妇幼保健院检验科,江苏扬州225001

出　　处：《国际检验医学杂志》2015年第23期3411-3412,3415,共3页International Journal of Laboratory Medicine

摘　　要：目的调查扬州地区女性人乳头瘤病毒（HPV）感染情况,分析其基因型及年龄分布特征。方法收集该院妇科2014年1月至2015年2月收治的4 422例不同年龄段患者宫颈脱落细胞标本,采用反向斑点杂交-基因芯片技术检测21种HPV基因分型。结果 HPV阳性率为38.60%,高危型HPV单型感染阳性率为18.23%,多重基因型感染阳性率为13.61%;以HPV-16、52、58、53、11基因型感染为主。30岁以下女性HPV阳性率略高于30~〈40岁者,之后随年龄的增大而逐渐升高。结论扬州地区女性宫颈HPV感染以HPV-16、52、58基因型为主,多重基因型感染阳性率较高,且HPV阳性率随着年龄增加而逐渐增高,需要针对不同年龄段、易感人群定期进行HPV核酸检测及基因分型筛查。Objective To investigate the prevalence of human papilloma virus（HPV）infection of women in Yangzhou region,and to analyse characteristics of genetypes and ages distribution.Methods A total of 4 422 cervical exfoliated cell specimens were collected from women in different age groups,from January 2014 to February 2015,recruited by gynaecologic department of this hospital.And 21 kinds of HPV genetypes were detected by using the dot blot hybridization reverse-gene chip technique.ResultsThe positive rate of HPV was 38.60%.The rate of high risk HPV infection was 18.23%,while the positive rate of multiple HPV subtypes infection was 13.61%.The genetypes mainly were HPV-16,52,58,53,11.The positive rate of HPV in women under 30 years old was slightly higher than that in women 30-40 years old,and the positive rate was elevated with the increase of age.Conclusion The dominant genetypes are HPV-16,52,58 in women with HPV infection in Yangzhou region,and the positive rate of multiple HPV subtypes infection is relatively high.Additionally,the positive rate is elevated with the increase of women′s age.It is necessary to carry out HPV nucleic acid detection and genotyping detection for women in different age groups and the susceptible population.

关 键 词：人乳头瘤病毒 基因分型 亚型 

分 类 号：R737.33[医药卫生—肿瘤]