双相情感障碍患者治疗前后性腺激素水平变化及相关性  

Changes of sex hormone levels before and after treatment and their correlation in bipolar disorder patients

作　　者：秦金[1] 孙喜蓉[1] 张少君[1] 闵婕[1] 金莹[1] 袁杰[1] 

机构地区：[1]上海市浦东新区精神卫生中心,200124

出　　处：《检验医学与临床》2015年第23期3466-3468,共3页Laboratory Medicine and Clinic

基　　金：上海市浦东新区卫生系统优秀青年医学人才培养基金资助项目(PWRq2012-07)

摘　　要：目的探讨双相障碍躁狂相、抑郁相与性腺激素的关系。方法选取诊断符合国际疾病分类诊断标准的双相情感障碍躁狂发作患者30例和双相情感障碍抑郁发作患者30例,入组后及治疗1个月后检测性腺激素(6项)。结果双相躁狂组男性患者治疗前血清睾酮水平显著高于治疗后及健康对照组睾酮水平,双相抑郁组患者治疗前血清雌二醇(E2)水平显著低于治疗后血清E2水平及健康对照组E2水平。结论睾酮与双相躁狂男性患者相关,E2与双相抑郁患者相关。Objective To investigate the relationship of bipolar mania,bipolar depression and sex hormone levels.Methods To select 30 patients with bipolar mania（bipolar mania group）and 30 patients with bipolar depression（bipolar depression group）diagnosed according to the 10 th revision of the International Classification of Diseases,and to detect the sex hormone（6items）levels respectively before and after one-month treatment.Results Serum testosterone（T）of male patients in bipolar mania group before treatment significantly higher than after treatment and that of normal control group.Serum estradiol（E2）levels of the patients in bipolar depression group before treatment was significantly lower than after treatment and that of normal control group.Conclusion Testosterone is associated with bipolar mania in male patients,while estradiol is associated with bipolar depression.

关 键 词：双相情感障碍 性腺激素 睾酮 雌二醇 

分 类 号：R749.4[医药卫生—神经病学与精神病学]