抗磷脂抗体综合征的临床表现及抗体研究进展  

Clinical Manifestations of Antiphospholipid Syndrome and Research Progress in the Antibodies

作　　者：李慧[1] 陈兴国[2] 蒋真[1] 潘文友[1] 

机构地区：[1]南京医科大学附属淮安第一医院风湿免疫科,江苏淮安223300 [2]南京医科大学附属南京医院风湿免疫科,南京210006

出　　处：《医学综述》2015年第23期4325-4328,共4页Medical Recapitulate

摘　　要：抗磷脂抗体综合征临床表现复杂多样,主要有血管血栓事件和习惯性流产,但其他的相关临床表现在诊断中也越来越被重视。除了已有的3种实验诊断标志物,抗凝血酶原抗体、抗β_2糖蛋白I新的结构域抗体、抗磷脂酰乙醇胺抗体、抗负电荷磷脂抗体、抗波形蛋白抗体、抗膜联蛋白抗体都具有一定的敏感性和特异性。其中该抗β_2糖蛋白Ⅰ结构域Ⅰ抗体和抗凝血酶原抗体可能是将来临床诊断应用的新标志物。The clinical manifestations of antiphospholipid syndrome （APS） are complex and diverse, mainly including a history of venous or arterial thrombosis and/or habitual abortion, but more and more attention is being paid to other related clinical manifestations for diagnosis. In addition to the existing three experimental diagnostic markers, anti-prothrombin antibodies, anti-β2-GPI new domain antibodies, antibodies against phosphatidylethanolamine,anionic phospholipids other than cardiolipin and vimentin, annexins have certain sensitivity and specificity. The anti-β2-GPI domain I antibody and anti-prothrombin antibody may be the new markers for the clinical diagnosis in future.

关 键 词：抗磷脂抗体综合征 血栓形成 抗体 Β2糖蛋白I 凝血酶原 

分 类 号：R593.2[医药卫生—内科学]