XRCC1基因多态性与肝细胞癌易患性的关联性研究  

The Association Study of XRCC1 Gene Polymorphism and Hepatocellular Carcinoma Suspetibility

作　　者：龚文锋[1] 张秋明[2] 钟鉴宏[1] 白涛[1] 黄山[1] 向邦德[1] 马良[1] 黎乐群[1] 

机构地区：[1]广西医科大学附属肿瘤医院肝胆外科,南宁530021 [2]广西医科大学第十附属医院综合病区,广西钦州535000

出　　处：《医学综述》2015年第23期4337-4340,共4页Medical Recapitulate

基　　金：国家自然科学基金(81160262);广西科学技术厅(桂科攻2011GXNSFD018032)

摘　　要：目的评价X线交叉互补修复基因1（XRCC1）Arg280His位点基因多态性与肝细胞癌（HCC）发病风险的关联性。方法检索PubMed、EMABSE及中国知网等数据库，收集关于XRCC1 Arg280His基因多态性与HCC易患性的病例对照研究，提取数据进行Meta分析。以病例组及对照组XRCC1 Arg280His基因型分布的比值比（OR）为效应指标，计算合并OR值及其95％置信区间（CI）。结果共7篇文献符合纳入标准，累计病例1448例，对照1529例。Arg／Arg基因型与His／His基因型比较的OR=0．69（95％CI 0．47～1.01，P=0．05）。而Arg／Arg基因型与Arg／His＋His／His基因型比较的OR=0．78（95％CI 0．52～1．17，P=0．24）。Arg-allele与His—allele比较的OR=0．74（95％CI 0．52～1．04，P=0．09）。结论XRCC1 Arg280His位点基因多态性可能不参与HCC的发生。Objective To explore the association between X-ray repair cress-complementing group 1 （ XRCC1 ） Arg280His polymorphism and risk of hepatocellular carcinoma （ HCC ）. Methods PubMed. EMBASE and the Chinese National Knowledge Infrastructure databases were systematically searched to iden tify relevant studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were used to assess the strength of the association. Results Altogether 7 studies were included in the meta-analysis,involving 1448 cases and 1529 controls. The XRCC1 Arg280His polymorphism were not significantly associated with increasing or decreasing risk of HCC （ Arg-allele vs His-allele ： OR = 0.74,95% CI 0. 52-1.04, P = 0. 09 ; Arg/Arg vs His/His： OR = 0. 69,95 % CI 0. 47-1.01, P = 0. 05 ; Arg/Arg vs Arg/His ＋ His/His ： OR = 0. 78,95 % CI 0. 52-1.17 ,P =0.24）. Conclusion XRCC1 Arg280His polymorphism may not be involved in HCC.

关 键 词：肝细胞癌 X线交叉互补修复基因1 多态性 Meta分析 

分 类 号：R735.7[医药卫生—肿瘤] R181.23[医药卫生—临床医学]