胃癌和结肠癌小肠细菌过度生长情况分析  

Small intestinal bacterial overgrowth in patients with gastrointestinal cancer

作　　者：梁素妨 许琳[2] 王静[1] 吴振军[3] 张东生[4] 李媛[2] 马晓莹[2] 

机构地区：[1]青岛大学,山东青岛266000 [2]青岛大学医学院附属青岛市市立医院消化内科,山东青岛266000 [3]青岛大学医学院附属青岛市市立医院临床输血与检验科,山东青岛266000 [4]青岛大学医学院附属青岛市市立医院肝胆外科,山东青岛266000

出　　处：《中国微生态学杂志》2015年第12期1417-1420,共4页Chinese Journal of Microecology

基　　金：青岛市医疗卫生优秀人才培养项目资助(13-1-3-14-nsh)

摘　　要：目的探讨胃癌、结肠癌小肠细菌过度生长(SIBO)的情况,及应用益生菌治疗SIBO后能否改善肿瘤患者的临床症状。方法 86例消化道恶性肿瘤患者分为胃癌组和结肠癌组,两组患者均通过葡萄糖氢呼气试验(GHBT)检测其SIBO发生率,并与对照组进行组间比较分析。对于消化道恶性肿瘤中检测SIBO阳性者,分为益生菌治疗组和安慰剂组,比较其治疗前后SIBO阳性率及患者临床症状评分的变化。结果 (1)86例消化道肿瘤患者中,54例(62.8%)GHBT阳性;30例对照组中3例(10.0%)GHBT阳性,两者比较差异有统计学意义(P<0.01);(2)给予双歧三联活菌胶囊治疗后,益生菌组22例(81.5%)SIBO转阴;安慰剂组6例(22.2%)SIBO转阴,且两组患者给药后的临床症状评分对比差异有统计学意义(P<0.05);(3)益生菌组治疗前后症状评分比较差异有统计学意义(t=3.681,P<0.05),而安慰剂组治疗前后症状评分比较差异无统计学意义(P>0.05)。结论消化道肿瘤恶性患者容易发生SIBO,益生菌治疗可通过抑制SIBO改善肿瘤患者的临床症状。Objective To discuss the condition of small intestinal bacterial overgrowth（SIBO）in patients with gastric cancer and colon cancer,and study whether the clinical symptoms of the patients can be improved by using probiotics against SIBO.Methods Patients with digestive malignancies（n=86）were divided into Gastric cancer group or Colon cancer group respectively.Glucose hydrogen breath test（GHBT）was used to diagnose SIBO,with healthy volunteers as the controls.The patients tested as SIBO positive were divided into Probiotics group or Placebo group respectively.Then the incidence of SIBO and clinical symptom scores of patients were compared between the two groups.Results（1）Of all the 86 patients with digestive malignancies,54（62.8%）were SIBO positive;In contrast,3out of the 30 healthy volunteers（10.0%）were SIBO positive;The difference was statistically significant（P 0.01）.（2）After treatment with Bifidobacterium triple viable capsule,22（81.5%）cases in Probiotics group vs 6（22.2%）cases in Placebo group turned to SIBO negative,and there was statistically significant difference between the two groups in clinical symptom scores（P〈0.05）.（3）After treatment,the clinical symptom scores of patients in Probiotics group was significantly improved（t=3.681,P〈0.05）,while in Placebo group,the difference of clinical symptom scores before and after treatment was not statistically different（P〉0.05）.Conclusion Patients with gastrointestinal cancer are prone to SIBO;Probiotics treatment can improve the clinical symptoms of patients through inhibiting SIBO.

关 键 词：消化系统 恶性肿瘤 小肠细菌过生长 葡萄糖氢呼气试验 益生菌 

分 类 号：R574[医药卫生—消化系统]