补肾养阴清火法治疗慢性牙周炎的临床疗效和对龈沟液中IL-1β、IL-6的影响  

Effects of Bushen Yangyin Qinghuo therapy on periodontitis and IL-1β, IL-6 level in ginggival crevicular fluid

作　　者：张芳[1] 陈燕[1] 蔡哲[1] 路东升[1] 李婧[1] 李宜磊[1] 舒骏[1] 郭丽丽[1] 王晓霞[1] 

机构地区：[1]中日友好医院,北京100029

出　　处：《中华中医药杂志》2015年第12期4324-4327,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:观察补肾养阴清火法治疗慢性牙周炎的临床疗效和对牙周局部炎性免疫因子的影响,探讨中药辅助治疗慢性牙周炎的临床可行性。方法:慢性牙周炎患者分成试验组和对照组,对照组进行牙周基础治疗和根面平整,试验组在牙周基础治疗1个月后口服中药调理,3个月后比较两组治疗前后牙周探诊深度(PD)、牙龈出血指数(BI)和龈沟液中白介素-1β(IL-1β)、白细胞介素-6(IL-6)的变化。结果:试验组和对照组PD、BI组内比较,治疗3个月均比治疗前明显减少(P<0.05),但两组间治疗前后差值比较,差异无统计学意义。试验组和对照组龈沟液中IL-1β和IL-6组内比较,治疗3个月均比治疗前明显降低(P<0.05),两组间治疗前后差值比较,差异有统计学意义(P<0.05)。中医主症候群和次症候群评分试验组治疗3个月较治疗前降低明显,差异有统计学意义(P<0.05),次症候群两组间治疗前后差值比较,差异有统计学意义(P<0.05)。结论:牙周基础治疗和根面平整是牙周治疗的有效方法,中药调理可以调节机体免疫,辅助降低龈沟液中炎性因子的水平。Objective： To observe the effects of Bushen Yangyin Qinghuo therapy on chronic periodontitis and local periodontal immunity, and explore the feasibility of adjuvant therapy with traditional Chinese medicine. Methods： Patients with chronic periodontitis were divided into experimental group and control group. The control group accepted the periodontal basic treatment and root planning, while the control group accepted the oral traditional Chinese medicine after periodontal basic treatment and root planning for a month. There months later, the change of PD, BI and Interleukin-1β（IL-1β）, Interleukin-6（IL-6） in gingival crevicular l uid was compared between experimental group and control group. Results： Compared with before treatment, the PD and BI after treatment decreased dramatically both in experimental group and control group（P〈0.05）, but there was no statistical difference in the change of PD and BI between experimental group and control group. Compared with before treatment, the level of IL-1β and IL-6 after treatment decreased dramatically both in experimental group and control group（P〈0.05）, and there was statistical difference in the change of IL-1β and IL-6 between experimental group and control group（P〈0.05）. The scores of main symptom group and secondary symptom group decreased dramatically in experimental group（P〈0.05）. There was statistical difference in the change of secondary symptom between experimental group and control group（P〈0.05）. Conclusion： Basic periodontal treatment and root planning had a good effect on periodontitis. Traditional Chinese medicine could regulate the body＇s immune function, which would help to inhibit the level of inl ammatory factor in ginggival crevicular l uid.

关 键 词：慢性牙周炎 中药 龈沟液 白介素-1Β 白介素-6 

分 类 号：R781.4[医药卫生—口腔医学]