子宫内膜异位症合并不孕者STAT3基因多态性分析  

Correlation between STAT3 gene polymorphisms and endometriosis &infertility

作　　者：黄蓉 陈亦欣[2] 王玲 许世艳 宋丽杰 王沙燕[3] 

机构地区：[1]深圳市人民医院妇产科,深圳518020 [2]深圳市人民医院肿瘤研究所,深圳518020 [3]深圳市人民医院法医物证中心,深圳518001

出　　处：《生殖医学杂志》2015年第12期1034-1037,共4页Journal of Reproductive Medicine

基　　金：深圳市2014年科技计划项目(JCYJ20140416122812010)

摘　　要：目的探讨STAT3基因多态性与子宫内膜异位合并不孕症之间的相关性。方法选取2013年6月至2014年6月深圳市人民医院收治的子宫内膜异位症合并不孕症妇女30例和同期体检健康的妇女35例为研究对象。采用PCR-RFLP法对两组妇女进行STAT3基因多态性检测。结果 STAT3基因rs2293152多态性位点的C、G等位基因频率在观察组和对照组中分别为70.0%、30.0%和90.0%、10.0%,两者相比差异具有统计学意义(P<0.05)。观察组CC纯合型17例,CG杂合型8例,GG纯合型5例,分别占总数的56.7%、26.7%和16.6%;对照组CC纯合型30例,CG杂合型3例,GG纯合型2例,分别占总数的85.7%、8.6%和5.7%,两组间差异有统计学意义(P<0.05)。此外,与CC基因型相比,携带G等位基因的基因型(CG+GG)可能增加了子宫内膜异位合并不孕症的发病风险[OR=4.59,95%CI(1.40,15.09)]。结论STAT3基因(rs2293152)多态性可能与子宫内膜异位症合并不孕症的易感性相关。Objective：To investigate the correlation between STAT3 gene polymorphisms and endometriosis infertility.Methods：Thirty patients with endometriosis and infertility who visited our hospital from June 2013 to June 2014 were selected as the observation group.At the same time,35 healthy women were selected as the control group.STAT3 gene polymorphisms of the patients in the two groups were detected by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）method.Results：The frequency of STAT3 gene polymorphisms of C（70% vs.30%）and G（90% vs.10%）allele were significantly different between the observation group and control group respectively（2χ=8.320,P〈0.05）.There were 17 cases of CC,8cases of CG and 5cases of GG types in the observation group,which accounted for 56.7%,26.7% and 16.6% respectively.There are 30 cases of CC,3cases of CG and 2 cases of GG types in the control group,which accounted for 85.7%,8.6% and 5.7%respectively.The difference was significant between the two groups（2χ=6.810,P〈0.05）.In addition,genotype G allele（CG＋GG）increases the risk of endometriosis associated with infertility compared with the CC genotype[OR=4.59（95%CI=1.40-15.09）]（P〈0.05）.Conclusions：STAT3 gene（rs2293152）polymorphism may be associated with endometriosis and infertility.

关 键 词：信号转导和转录激活因子-3 子宫内膜异位症 不孕症 

分 类 号：R[医药卫生]