射频热疗联合适形放疗治疗肝癌的近远期疗效分析  

Short and Long Term Effect Analysis of Radiofrequency Hyperthermia Combined with Conformal Radiotherapy in Treatment of Liver Cancer

作　　者：安毅[1] 龚文锋[2] 康凯[1] 蝴已乐 高金保[1] 郝广军[1] 

机构地区：[1]陕西省榆林市第一医院消化内科,陕西榆林719000 [2]广西医科大学附属肿瘤医院肝胆胰脾外科,广西南宁530021

出　　处：《医学临床研究》2015年第11期2194-2196,共3页Journal of Clinical Research

摘　　要：【目的】探讨射频热疗联合适形放疗治疗肝癌的近远期疗效。【方法】收集本院2012年3月至2014年3月收治的80例肝癌患者，依据随机数字表法将患者分为对照组和观察组，每组40例。对照组给予单纯适形放疗，观察组在对照组的基础上联合使用射频热疗，比较两组患者近期及远期疗效。【结果】治疗后两组患者的胆红素（TBIL）、谷丙转氨酶（ALT）和凝血酶原时间（PT）水平均降低，且观察组降低的更明显，白蛋白（ALB）水平均升高，且观察组比对照组ALB升高的更明显，差异均有统计学意义（ P ＜00．5）。观察组患者的总有效率显著高于对照组，差异有统计学意义（ P ＜00．5）。随访发现，观察组患者6个月和1年的肿瘤复发率及患者的病死率均显著低于对照组，差异均有统计学意义（ P ＜00．5）。【结论】射频热疗联合适形放疗治疗肝癌近远期效果显著，提高了患者远期生存率，值得临床推广。Objective]To study the short and long term effect of radiofrequency hyperthermia combined with confor‐mal radiotherapy in treatment of Liver cancer .[Methods]Eighty patients with liver cancer from March 2014 to March 2012 were randomly divided into the control group and the observation group with 40 cases in each group .The control group was treated with conformal radiotherapy ,and the observation group with radiofrequency hyperthermia on the basis of the control group .The short‐term and long‐term effects of the two groups were compared [.Results]After treatment , the serum bilirubin （TBIL） ,alanine aminotransferase （ALT） and prothrombin time （PT） levels were decreased in the two groups ,the observation group decreased more significantly ;the levels of serum albumin （ALB） of the two groups were increased ,and the observation increased more significantly than the control group ,the difference was statistically significant （ P 〈0 0.5） .The total effective rate of the observation group was significantly higher than that of the control group ,the difference was statistically significant （ P 〈0 0.5） .The 6~12 months follow‐up found that the recurrence rate and mortality of the patients in the observation group were significantly lower than those in the control group ,the differ‐ence was statistically significant （ P 〈0 0.5）[.Conclusion]Radiofrequency hyperthermia combined with conformal radio‐therapy could greatly improve short and long term effects in patients with liver cancer ,upgrade their long‐term survival rate ,and it is worthy of clinical promotion .

关 键 词：导管消融术 高温  诱发 放射疗法  适形 肝肿瘤/放射疗法 

分 类 号：R735.7[医药卫生—肿瘤]