阿加曲班治疗短暂性脑缺血发作的临床观察  

Argatroban in treatment of patients with transient ischemic attack

作　　者：李晓泽[1] 柳青[1] 王秉卿[1] 李伟荣[1] 

机构地区：[1]太原市中心医院神经内科,030009

出　　处：《中华全科医师杂志》2015年第12期951-953,共3页Chinese Journal of General Practitioners

摘　　要：2011年7月至2015年3月观察在抗血小板治疗（100mg／d）基础上加用小剂量阿加曲班（10mg／次，持续泵入3h以上，每12小时1次，疗程7d）治疗41例短暂性脑缺血发作（TIA）患者的疗效（观察组），与行低分子肝素（2050AXa IU，每日2次脐周皮下注射，疗程7d）治疗的42例患者（对照组）相比较。开始治疗后1个月的痊愈、显效与有效例数，观察组分别为10、14和16例，对照组分别为6、12和16例。提示在阿司匹林抗血小板治疗基础上，加用阿加曲班治疗能改善TIA治疗效果，无明显不良反应。Eighty-three patients with transient ischemic attack （TIA） were randomly divided into study group （n = 42） and control group （n = 41 ） from July, 2011 to Mar, 2015. Patients in both groups were given aspirin 100 mg/d; in addition, patients in study group received intravenous infusion of argatroban 10 rag, ql2h, for 7 days and those in control group received subcutaneous injection of low molecular weight heparin （LMWH） 2 050 AXa IU, b. i. d for 7 days. The cases with cure, significantly effectiveness and effectiveness in study group and control group were 10, 14, 16 and 6, 12 16, respectively. Compared with the control group, argatroban shows superiority in treatment of TIA with higher safety and lower side effect.

关 键 词：脑缺血发作 短暂性 抗凝药 

分 类 号：R743.31[医药卫生—神经病学与精神病学]