灯盏花素对青光眼滤过术后中晚期原发性开角型患者视功能的影响  

Effect of Breviscapine on Visual Function of Patients with Primary Open-angle Glaucoma at Middle and Late Stage after Filtration Surgery

作　　者：杨君红[1] 俞颂平[1] 吴道雷[1] 

机构地区：[1]丽水市松阳县人民医院眼科,浙江丽水323400

出　　处：《中国药师》2015年第12期2082-2084,共3页China Pharmacist

摘　　要：目的:研究灯盏花素对青光眼滤过术后患者视功能的改善效果。方法:中晚期原发性开角型青光眼滤过手术后患者29例(42眼),根据视野缺损程度分层随机分组双察组15例(21眼)每日静滴灯盏花素50 mg,对照组14例(21眼)每日静滴维生素C注射液1g,两组均持续用药2周停药1周为1疗程,连续治疗3个疗程。比较两组患者治疗前后视功能。结果:治疗后,双察组视野缺损、视网膜神经纤维层均较治疗前显著改善(P<0.01或P<0.05)且治疗后观察组视力、视野缺损值均优于对照组(P<0.05或P<0.01)。结论:灯盏花素注射液能减轻眼压已控制的原发性开角型青光眼滤过术后患者视力的损伤对视野缺损具有改善作用。Objective： To study the effect of breviscapine on visual function of the patients with primary open-angle glaucoma after filtration surgery. Methods： Twenty-nine cases （42 eyes） of patients with primary open-angle glaucoma at middle and late stage after filtration surgery were selected and randomly divided into the experimental group and the control group according to the defect degree of visual field. The 15 patients （21 eyes） in the experimengtal group （TG） were intravenously injected 250ml saline containing 50mg breviscapine, while the 14 patients （21 eyes） in the control group （CG） were intravenously injected 250ml saline containing lg vita- min C. The treatment course was 2 weeks followed by one-week withdrawal. After three treatment courses, the visual function in the two groups was investigated and compared before and after the treatment. Results： After the treatment, the visual field defect value and the thickness of retinal nerve fiber layer of the patients in TG were both better than those before the treatment （P 〈 0.01 ,P 〈 0.05 ）. The values of visual acuity and visual field defect of the patients in TG were significantly better than those of the patients in CG （ P 〈 0.05, P 〈 0.01 ）. Conclusion： After intraocular pressure is controlled, breviscapine injection can reduce the vision damage of patients with primary open-angle glaucoma at middle and late stage after filtration surgery and improve the visual field defect.

关 键 词：灯盏花素 青光眼滤过术 视力 视野缺损 

分 类 号：R775[医药卫生—眼科]